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Homo sapiens (human) LEMD1 antisense RNA 1 (LEMD1-AS1) URS00003ED227_9606

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LEMD1-AS1: LEMD1-AS1 is a long non-coding RNA (lncRNA) that has been found to interact with miR-183-5p in Ago2-containing precipitates [PMC7395824]. It is part of a ceRNA network that includes 8 lncRNAs, 71 miRNAs, and over 200 mRNAs [PMC6019896]. Overexpression of LEMD1-AS1 in OSC3 cells led to upregulation of p-PI3K and p-AKT [PMC9381283]. LEMD1-AS1 expression was found to be decreased in several types of tumors, including ACC, BRCA, LGG, LIHC, OV, PCPG, PRAD, SKCM, TGCT, UCEC and UCS tissues compared to their corresponding normal tissues [PMC9365578]. Additionally, LEMD1-AS1 was identified as a useful tool for distinguishing EOC specimens from normal ovarian tissues using ROC assays [PMC9365578]. It has also been identified in ovarian cancer along with HAND2-AS1 (33), PART1 (34), and WDFY3-AS2 (35) [PMC8581474]. These findings highlight the potential role of LEMD1-AS1 in cancer development and suggest its potential as a diagnostic tool for ovarian cancer.

Genome locations

Gene Ontology annotations

Sequence

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AGUGAAUGCGGUCCUGUAAAUGCUGGCGAUCUUGUAGCAGUGCUGAUUAGCGAGUUGCUCCAACACCUCCUCAUAAUUUUUUCCUGCUCAUCACUCACCUGCUUUGUCAAAAUGAACAAGAAGGAAGCAUGAUUGAGCUGUGCACCGAGGCGGCAAGGAAGCCCUGGAUGACCCUCUUAACAGAGGCUGCCAAGGCUCCAGCGCCCACUUUCUCAGCCUCCCUUGCUGCUCAGGAUGAAAUAUGUAGAGCUGGAGAAGAGACAUGGUUAGUCCUUACGUCCUGCCUUAAAUGAUGAUGUGAUGGCCAUUAUCUGGAUCCUUCAUGGAAUUUCGGCAGUUCCAACGUGUCAGGCCAGUGUCUGGGAUUCUCUCAGCCUUUCGCUUUUUCCCCUGGGAGUCGGACAGCUGCUGCAGCUCAGUCAGACCAAACCUCUCUGAAUACCACCAAGAAUCGGGAUCUUGUUCUGUUGUCCAGGCUGGAGUGCAGUGGUACAAUCACAGCUCACUGCAGCCUUAACCUCCUGGGCUCAAGACAUCCUCCCACGUCUGCCUCUCGAGUAGCUCGGACCACAGAGUCACCCAGGCUGGAGUGUAGUGGCACGAUCUUGGCUAACUGUAACCUCUGCCUCCUGGGUUCAAGUAAUUCUCCUGCCUCAGCCUUCUAAGUAGCUGAGAUUACAGGCACUCUUCGCCGCGCCUGGCUAAUUUUUGUAUAAUAUUUUUAGCAGAGACGGGGUUUUGUCAUGUUGGCUAGGCUGGUCUCAAACACCUGGCCUCAAGCAAUCCACCCGCCUCAGCCUCCCAAAGUGCUGGGAUUACAGGUGUGAGCCACUGUGUCCAGCCCUUAUGUUUUAUUUAUUCAUUUAACAAUUAUUUGUUGCGUGCUGCUGAGUGCCAGGCCUGACGCCGGCUGUGAAGAUUUCAGAAGGGCCUGCCAAACCGUCCCUGUCCAAAACAGCUCACUAUCAAGCAUGGUUAUUUUGUAAGUGUUCUGCACUGGCUUCCUUCUUCCCUAAUCAGACCAUCUGUUGGAUCUCAUGGAGCUGUCUCCUAUUUCUCUGUAAUCAAGCCACAGUAUCUAACAUUUGGGGCCACUGGUAACUUGCCGUCUACUCCCAUGCUGGAAGCCCAGGACCCUUGAACAUAAGAGGCGCCUUCUGACACCUGCGGUGCUGUCAGAGCCUGCAGGCUGCAGACAGUGAGUCAGGAACUGGAGAAUUCCCAGGAGUGGUAUAAGGAGCUGGGACUCGCGUCAGACAGGGAAAGGACUGACAGAGACCAGGACAGAACAAGAAGCACAAGGAAAGUCAAGAGGAGAGUAAUGACCGCAAUCCCAAGGUAGACUGGACUGGAGUGUCUGGAGGGUCCGACAGGAGAAGGGCAUUUGUGUUCAUCACGGAGCUACUAGGAGAAAGAAGAGCCUGGGUCUUAGCAAGGAUGUGGUCAGGACACAACAAUAGAGUGGACCCCUCCAGUGAGUGUGGACUAUGACUUAUGGCAGGCCCAAGGGUCCCAGCGCAGGGUGGGGUGGGGAGGGCAUGGCUUGCUGUAGCAUCACGCACUGCUAGUCACCAUCUACCCAGUACAGGUCACCAAUGAUGGAACAGCUACAGCCUCCUCCCCUUCCCCUGUACUCCCUGUGCCCCCUUCUUUUUUUUUUUUGAGAUGGAGUCUCGUUCUGUCACCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUUACUGCAAGCUGCGCCUCCCAGGUUCACGCCAUUCUCCUGCCUCAGCCUCUCGAGUAGCUGGGACUACAGGCACCUGCCACGAUGCCUGGCUAAUUUUUUAUAUUUUUUAGUAGAGGUGGGGUUUCACUGUGUUAGCCAGGAUGGUCUCGAUCUCCUGACCUUGUGAUCCGCCCGCCUCAGCCUCCCAAAGUGCUGGGAUUACAGGCCUGAGCCACCGCGCCCGGCCCCUGUGCCCCCCUUCUUAAACAUGUUCUCAACAGUGGUUUAGCGAUACCCAAGCAAGGCCUUUGCAUAUGUGGGAAGUUGUGCACCAUGCAAGAGUGCCACAUGCAAACAGCACCUUUCCCCGUGUAGACACUGUAGAUUUACAUACCCUUACCACAUACCCUUCCAGGAACAGGGAAGCAAAGGCUCUUGAGGAAGAGAUUUCCCACAAAGGUGCUAUGUGGGUUAGUGUUGGCAUGCUCACCAAGAGAUAUUUCAAGCUAUUUCCAAGGGUAUUGGAAAAAUCAUUUAUAAGCAAAUUCUUUUUUUACUUAUGGAAAAUUUUAAGCAUAUACAAAAAUAGACAACAGUAUCAUGAACCUCUACAUAUCCAUCACAUGCAACUUCUUUUUAAUUCGCUUAAAUUUAAAAAUAGAUACGUGAAAUAAAGCAUUUGGGGCAGAAGUUCAUUGCAAAAUCAAAUGAUAGAAUUUCACAGCUCCUAGGCAAUCAAAUACUCCCCUUGUGCCAUAAGGAGAUUUAGGCCUUUUAUUUCCUUUUCUUUUACAAUUUGUUUUCUUUGCUAUCAUUCAUAUGUAGAGUUCUCCUGCAGUAUGUAGAAGGUGGACAUUGUCAUUUUCAAAAAUGGAGUAAUUAUGGCCUAUCUACCUGACUGUGCAGCUAUCAAUAAUAAUUAUUAUUAUAAAGGCCAUAUAACAGGGAAAAGCAUUAUUGAUUAGUGUUAAUAAACGGUAUAAAUUGUACAUAAACAGUGAUGUCUACUGUGUGAACAUAUACUAGAUAUGCAUGUAAACAAAAACUAGAGGUAAAUUGAAAAAAUAAAAUCAGUUUUUGCAUC

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