v24

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Homo sapiens (human) small nucleolar RNA, C/D box 86 (SNORD86) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, C/D box 86 (SNORD86) URS00003D103A_9606

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SNORD86: SNORD86, an orphan C/D box snoRNA, is encoded within the NOP56 pre-mRNA and exhibits significant nuclear enrichment in small granulosa cells [PMC8059229]. It functions as a sensor and "master switch" that controls the levels of the snoRNP protein NOP56 by dictating the usage of alternative splice sites [PMC8677010]. SNORD86 forms a secondary structure within the pre-mRNA that represses the distal splice site and activates the proximal splice site, resulting in exon skipping and the formation of a NOP56 mRNA that encodes the NOP56 protein [PMC6533054]. The structural switching mechanism of SNORD86 is governed by specific anatomical features and can adopt two alternate conformations: a "snoRNP conformation" when levels of snoRNP core proteins are high, and a "non-snoRNP conformation" when levels are low [PMC7200641]. SNORD86 has been implicated in autoregulating pre-mRNA splicing of NOP56 in cis, depending on the availability of different snoRNP proteins [PMC7200641]. It has also been shown to have extra-ribosomal functions, such as regulating alternative splicing of other pre-mRNAs like serotonin receptor 2C and sequestering RNA binding proteins [PMC8583065][PMC6533054][PMC7200641].

Genome locations

Gene Ontology annotations

Sequence

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GAUCACGGUGAUGGCUGACCAGGGCUCCCUGACCUAUACAGGCCUCUGCUAUGGGGGUGAUGGCCAGUCCUGGUGUCUGAGUGAUU

Taxonomic tree

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This sequence is found in 20 other species

  1. Aotus nancymaae small nucleolar RNA, C/D box 86 (ENSANAG00000009083.1)
  2. Camelus dromedarius (Arabian camel) small nucleolar RNA, C/D box 86 (ENSCDRG00005010982.1)
  3. Camelus ferus (Wild Bactrian camel) Small nucleolar RNA SNORD86
  4. Cebus imitator small nucleolar RNA, C/D box 86 (ENSCCAG00000008735.1)
  5. Cercocebus atys (Sooty mangabey) small nucleolar RNA, C/D box 86 (ENSCATG00000022016.1)
  6. Chlorocebus sabaeus (African green monkey) small nucleolar RNA, C/D box 86 (ENSCSAG00000021708.1)
  7. Colobus angolensis palliatus (Angola colobus) snoRNA (ENSCANG00000010170.1)
  8. Gorilla gorilla gorilla (Western Lowland Gorilla) small nucleolar RNA, C/D box 86 (ENSGGOG00000032461.2)
  9. Macaca fascicularis small nucleolar RNA, C/D box 86 (ENSMFAG00000023584.2)
  10. Macaca mulatta small nucleolar RNA, C/D box 86 (ENSMMUG00000032819.3)
  11. Macaca nemestrina (Pig-tailed macaque) small nucleolar RNA, C/D box 86 (ENSMNEG00000002690.1)
  12. Mandrillus leucophaeus (Drill) small nucleolar RNA, C/D box 86 (ENSMLEG00000012009.1)
  13. Pan paniscus small nucleolar RNA, C/D box 86 (ENSPPAG00000003035.1)
  14. Pan troglodytes small nucleolar RNA, C/D box 86 (ENSPTRG00000032706.2)
  15. Papio anubis (olive baboon) small nucleolar RNA, C/D box 86 (ENSPANG00000005585.3)
  16. Piliocolobus tephrosceles snoRNA (ENSPTEG00000032783.1)
  17. Pongo abelii small nucleolar RNA, C/D box 86 (ENSPPYG00000025076.2)
  18. Rhinopithecus bieti small nucleolar RNA, C/D box 86 (ENSRBIG00000029846.1)
  19. Rhinopithecus roxellana (Golden snub-nosed monkey) small nucleolar RNA, C/D box 86 (ENSRROG00000008436.1)
  20. Theropithecus gelada (gelada) small nucleolar RNA SNORD86 (ENSTGEG00000011070.1)
 2D structure Publications