MIR19B1: MIR19B1 is a member of the miR-17~92 cluster and has been associated with various conditions and diseases. It has been linked to the presence of right renal agenesis [PMC9090243]. Additionally, MIR19B1, along with MIR17, MIR18A, and MIR20A, is part of the miR-17–92 cluster on chromosome 13 that is upregulated in lung cancer cell lines and involved in repression of proliferation inhibition and apoptotic agents [PMC6418160]. In the context of malignancy, MIR19B1 has been found to be one of the most upregulated miRNAs [PMC9390975]. In individuals with non-syndromic CAKUT (congenital anomalies of the kidney and urinary tract), pathogenic variants in MIR19B1 have been identified [PMC7998154]. The miR-17~92 cluster genes, including MIR19B1, have been found to be encompassed by a microduplication at 13q31.3 [PMC4005632]. The host gene for the miR-17~92 cluster is MIR17HG, which encodes for six individual miRNAs including MIR19B1 [PMC4005632]. Copy gains or amplifications affecting this locus have also been found to impact the miR17-92 cluster genes [PMC9259584]. References: [PMC9090243] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090243/ [PMC6418160] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418160/ [PMC9390975] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390975/ [PMC7998154] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998154/ [PMC4005632] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005632/ [PMC9259584] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259584/