TRIM31-AS1: TRIM31-AS1 is a pyroptosis-correlated long non-coding RNA (lncRNA) that has been identified as a protective lncRNA in breast cancer (BC) patients [PMC9393225]. It is one of the six lncRNAs, including OCIAD1-AS1, MAFG-DT, SLC25A25-AS1, SNHG18, PSMB8-AS1, and TRIM31-AS1, that were selected and used to establish a predictive model for BC patients [PMC9393225]. High expression levels of TRIM31-AS1 were associated with better overall survival in BC patients [PMC9393225]. Interestingly, TRIM31-AS1 also displayed higher expression in colon organoids of familial adenomatous polyposis (FAP) patients compared to healthy subjects and in colon tumors compared to normal adjacent tissue (NAT) [PMC9396789]. However, no significant differences in survival were observed for TRIM31-AS1 in the TCGA-COAD cohort [PMC9396789]. TRIM31 antisense RNA 1 (TRIM31-AS1) is one of the genes that mapped within colorectal cancer (CRC) genome-wide association study (GWAS) loci [PMC9396789]. A differentially methylated region adjacent to TRIM31-AS1 and TRIM31 was found to be significantly hypomethylated in FAP and CRC tumors compared to healthy subjects and NAT [PMC9396789]. The specific role of TRIM31-AS1 in CRC has not been determined yet; however, its increased expression may be important for protein regulation through its binding with protein-coding mRNA [PMC9396789]. References: [PMC9393225]