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Homo sapiens (human) hsa-miR-4442 URS00003AD80B_9606

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hsa-mir-4442: Recent studies have confirmed that the plasma levels of hsa-mir-4442 in patients with DM changed significantly before and after treatment, which may serve as a potential biomarker [PMC8464434]. In one study of a Japanese cohort, levels of hsa-mir-4442 were found to be positively correlated with Skeletal Disease Activity in MITAX (Myositis Intention to Treat Activity Index), with a decrease in levels after treatment with prednisone [PMC8033302]. Other miRNAs, such as hsa-miR-181c-5p, hsa-miR-642a-3p, and hsa-miR-1254, were also analyzed [PMC6740188]. qRT-PCR was performed to validate the differential expression of hsa-mir-4442 and it was confirmed that the levels were decreased by treatment [PMC5757292]. The expression of hsa-mir-4442 was compared between patients with PM/DM, other autoimmune diseases (RA and SLE), and healthy individuals [PMC5757292]. The study suggested that hsa-mir-4442 may be associated with PM/DM and could be a potential biomarker for diagnosis or disease activity [PMC5757292]. However, no correlation was found between the expression level of hsa-mir-4442 and serum autoantibody profiles [PMC5757292]. The plasma expression of hsa-mir-4442 was significantly higher in active PM/DM compared to active RA, active SLE, or healthy controls [PMC5757292]. Further studies are needed to investigate the significance of hsa-mir-4442 in the development and progression of autoimmune myositis as well as its cellular source and functional role in PM/DM pathogenesis [PMC5757292].

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Gene Ontology annotations

Sequence

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GCCGGACAAGAGGGAGG

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