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Homo sapiens (human) long intergenic non-protein coding RNA 1446 (LINC01446) URS00003AA7A2_9606

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LINC01446: LINC01446 is a long non-coding RNA (lncRNA) that has been found to play a role in promoting gastric cancer (GC) cell proliferation and metastasis by epigenetically silencing RASD1, a member of the Ras family of monomeric G proteins, through the recruitment of LSD1 to the RASD1 promoter [PMC9898530]. Additionally, an increased level of LINC01446 has been detected in glioblastoma compared with healthy cells [PMC9813052]. This finding was based on the analysis of data from the public dataset GSE51146 and the examination of 31 pairs of glioblastoma multiforme samples and neighboring normal tissues derived from patients [PMC9813052]. LINC01446 is an example of an lncRNA that has been implicated in cancer progression. It exerts its effects by epigenetically silencing RASD1, which is involved in cell signaling pathways. The recruitment of LSD1 to the RASD1 promoter by LINC01446 contributes to this silencing effect [PMC9898530]. In gastric cancer, LINC01446 promotes cell proliferation and metastasis through this mechanism. Furthermore, increased expression levels of LINC01446 have been observed in glioblastoma compared with healthy cells. This finding suggests that LINC01446 may also play a role in glioblastoma progression [PMC9813052]. The analysis was based on data from GSE51146, which is a public dataset containing gene expression profiles. Additionally, 31 pairs of glioblastoma multiforme samples and neighboring normal tissues were examined to validate these findings [PMC9813052]. In summary, LINC01446 is an lncRNA that promotes gastric cancer cell proliferation and metastasis by silencing RASD1 through LSD1 recruitment. It also exhibits increased expression in glioblastoma, indicating its potential involvement in glioblastoma progression. These findings were supported by data from public datasets and patient samples [PMC9898530] [PMC9813052].

Genome locations

Gene Ontology annotations

Sequence

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GACAGAAGAUGGCGGAUGAGCAGCGUGCAGGGUUUUCUCCCUGUGGCUCACUCUCUCUUACUGUGCUGGGCGGUUGCUUCCUCUCCUGCUGCCCUUGGGAGUCAGACUCCAGGUUCUUCAGCCUGUGGCCCCUGGGGCUCUCGGGCCUUGGAGGACUGACUAGGAGCACACGGUGGGCCUCUCUGGUUUGGGGGCCUGGGACGUGGCGGAGCCCUGCAGCUUCUGUGCGGCCUGUUCUGGGCGUCGCGUUGAAACGCCAGCCAGUUCCCCAAGUAAGCUCCCUGCACACACGCCUGAUAGCCUGUUGGUUCCGUCCUUCUGCGGGAUUUUCACUACCACUCUCUAACUCACACACAGCAGAAAGAGCAUACGGGAGAGAUGAAGCAGUCCACUCCAAGAACAUUCUCAUCCUACGGAUUACGAGUCCCCCUGGGAUUACAGGAGUGUUGAAGAAAUGUUGUGACACAUCAGAACACCGCGAAAUACAUGGACACUUUCAAAUCAUGGAAGACUCAAGAAGAAACUUUAAUUAGAAGGAAACAGGAAUAUUCAACGGACUCCCAAGACAAGAAUAUAGAUGUAUAUCAGAAGCUGAGCAUUGAAGUUGCUACUAGAGUCUCCCCGAGCCCUUAUUGGAUUCUCACUUCAGGAGCUGCUUUCAUUAUUUUGCCUCUCAGUUUCAAAAUAGACAAAGAACUCAACACUCAACAAUAAGAAAAUGAACAACUUGGUUGAAAAAUGGGCCAAAGACCUUAACAGACACCUCACCAAAGAUGAUAGACAGGUAGGAAAUAAACAUAUAAAAAGAUGCUGCACGUCAGAUGUCAUCAGAAAAGUGCAAUUAAAACAACAAUGAGACACCACUAUGCAUCUCCUAGAAUGACCAAAACCCAGAACACUGACACCAAAUACUCUUGAGGAUGUGGAGCAAUUCUCAUUGCUGAUGGGAAUGCAAAAUGGUACAGUCUUUUGGAAGACAGCUUGGAGGUUUCUUAUAAAGCUAAACUUGGAUUUACCAUACCAUCUACCAGCAGUGCUCCUUGGUAUUUACCCAGUGGAGCUGAAAAUGUAUGUCCCCACAGAAAAACAGGCACGUGGACGCUUACAGAAGUUUUACACAUAAUUUCCAAGACUUGGAAGCAACCAAGAUGUCCUUCAGUCGGUGAAUGGAAGAAUAAACUGUGGAACAAUCAGACCAUGGAAUAUUAUUCAGUGCUGAAUAGAAAUGAGCUAAGAAAGCCAUAAAAAAACAUGGAGGAAAAAAUGUUCAACACCAAGACUGAACCCUAAUGUAACCUGUGGACUUUGGAUGAUAAUGACGCAUCAAUGCAAGUCAUAAAUUUGGAAAAAUGUACCUCUCCUGGGAAGGAGUUGAUAAUGAGGUCAGGAGGGCAUCUUUCUCGGCUCUUCACUGUGAGAACCUUGUGGGAUUCCUGAAGAUGAAACCAUGAACGCGAGGGAGUCUUGCUAAAACUGCAGCAUUCGAGAGGUUUUCACUCAUGCUGGCUCACACUUGUCCUCUAGCAAUUCAUCAAAAUUACCACGACAAAGAAGACAGAAAAUACUACACACUACCCAGAGAUUGAAACUGAAGGUGUGAACAACAGAGAAAAGAGAGGGCAAAGAAAAGGAAAACAAAGAAGACGUGGGAUAUGAAAGGUGUAUGCCAUGUGUGGACAUCAAGAAAUGUUUCAGCUCGCACUUCUGCCACCAAUUGAGCCUGGAACCUCACUACUUGGAGUUGGGGGGAGGGCAGUGCUCAUUCAUCACCUGUGAAAAUAGGGAUUGAGAGUUCCCUAACUUUGCCAUUUUUCCUCAAGCACUGGCAUUGGUCUUCUGAAUGUCAGGCUCUGUAUAAGUGAGUCCUCAGCUGAGCCACAGGCUCUGCAUUCCUGGCAGUCCACACACUUCAUAUCCUUUGUUUAUGCUGCUCAUUUUGGAAUUCAAACAGGUUGGUGGGGCACAUUUCAACAGAUAAUGACACACACUGACUGCUCAUGAGCUAUUUUAUGGUGUGAGAAUGUUGUGAUGUUAUGAAAUGCGGAGGCAUUAAAACAUGGGGACAUUUUCUAGAAGAUCCUUAGCAGAGAGUACAGAAGACUAAGGUCCAAAUCUCUGAAAUGAUGUUUUCCAAAUUAUUGCACAGCUAUGUCAAAGUACCUUGAUCCAGUUAAUGUUAACAAAUAAAAAAUUAUGAAAUGUUAUUUUCUAGGUAUGGAUAGUAGUGGAUAGUAGUAGAUCUGUUGUGUAGUGGAGAUUACUUAGGAAGAAUAAAUUUCAACUUUACCAAGAAAGUACUACAUUAAUUGCAUUAGGGAAUUGUGAAUUGCAUUAGGAAAAUGCUCAUUCUUCUUUCAAUAGCCAAUAUCUGGAUACUAUACUCUCUUGAAUUUCUAAGAUUUGCAUCCAAUAUUCUAUAAUUAGCUUUCCAGUUUAUUGAAUGAUUUAAUUUACAUACAAAUAUUUUCUAAUAUAUUCCCUGUAAAAUAGUUUAAAAAAUUAAACGUUUCUCUAAUUACACAUUCCUCCCUAGCUGAUACAAUUUCAUUUAUUUGCUUACUUUCCCAGCUGGACAUUCAGAAAUUUUUUACUCAUAUUGUCUUCAAUUGCAUAUUUGCCAGUUUCUAGCUUUUAUUUUAUUUUUUAUAUCCAUUUUGUUCUAGGUGUGGAAAUUGCUAAGUGUAGAGCUUAAUAAUAUUUCACCAGAAAGAUAUGUGUCUAACUCCCUCAUGAAGAAAUAGUAUGUUACCAACACUCCCAAAUUUCCUUUGAUGUCAAAAAGCAUUAUUUUUCUCGAGUCUUUUUUUGUGUUGGUAUGAUAUAUAAACGAAAUCAUAUACACAUUUAUUUUUUCAUUUAGAUACUUUCCUUCAGUAUUAUGAUUGAGACAUUAACCUCAGUUUAAGUAUUUAUGUCAUUUUCAUUGCUAGUUCAUUGUAAGAAGCACACCUUUUAUUUAUCUAUUCCCUUAAUACAUAUUCCUGUUUCCAGUGUUAGAUUAAUGCAAAUAAGGCUAUCGUGAGCAUUCUUUUACAUGUUUUUCAGUGUACAAAUAUAUGCUGAGAGAGGAAUUACUGAAUCACAGAAAGCAGUAUAUGCAGCUAUAAUAGAUAUUACCAUAUCCACCAAACGUUUAGCAUUUCCUGUUUCAUUUUAUUCACUCUGGGGGAUGUAUAGAGAUUUCACAUUACAUUAUAAUUUAAUUUCUCUAAUGUCUAAUGAUGGGGAGCACCUUUUUCAUGUUUUUAUUGUCAAUUUGGCUAUCUUCUUUUUCUAAAUGCAUGUUCAAGUAUUUCAUCCAUUUUUAUUGGUCUUCUUUUUUUACUGGUUUAAUUGAAUUCUUUACAUAUUAUGGAUAUGAGCUCUUUGUCAAUUUUAUAUGUAUGCUUAUAUUCACUCCUACUUCACUCUGCAGCUUGCUUUUUAUUUUUAUGCUUUUAAUAAUGAACAUAAUUUCUUUAUUUUAAUAAAUAUCAUUAUUUUU

Taxonomic tree

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Expression New Publications