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hsa-mir-539: Hsa-mir-539 is a microRNA that has been found to be over-expressed in various diseases, including hepatocellular carcinoma (HCC), pancreatic neuroendocrine tumors (PNETs), and colon cancer [PMC3440352] [PMC7894801] [PMC4268797] [PMC7295234] [PMC7352720] [PMC7850735] [PMC8873361] [PMC9941246]. It has been shown to be altered at least four-fold in HCC and highly expressed in PNETs and PDACs, indicating its potential role as a biomarker for these diseases [PMC3440352] [PMC7352720]. Additionally, hsa-mir-539 has been found to be associated with prognosis in HCC patients, with its expression levels correlating with patient outcomes across different datasets [PMC7467934]. Furthermore, hsa-mir-539 is part of a miRNA signature that includes other miRNAs such as hsa-miR-549, hsa-miR-518b, and hsa-miR-152, which have also been associated with prognosis in HCC patients across different datasets [PMC7467934]. These findings highlight the potential of hsa-mir-539 and other miRNAs as prognostic markers for HCC.
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