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SNORA37: SNORA37 is a small nucleolar RNA (snoRNA) that is 93.8% identical to SNORA30B [PMC8178906]. It is one of the many snoRNAs that are involved in non-coding RNA regulation [PMC5747948]. In pathological liver conditions, SNORA37, along with SNORD115-31 and SNORD121B, was found to be negatively regulated [PMC9454744]. In the context of colorectal cancer (CRC), SNORA37 was identified as one of the six candidate snoRNAs with high fold change and abundance, suggesting its potential role in CRC [PMC7559222]. Additionally, high abundance of SNORA37 was associated with early biochemical recurrence in intermediate-risk prostate cancer patients [PMC8465891]. It has been found that SNORA37 regulates cancer cell lipid synthesis through histone modification [PMC8114150]. In the context of FUS knockout cells, increased levels of pseudouridylation at specific sites were accompanied by elevated levels of corresponding snoRNAs, including SNORA37 [PMC9941101].
Overall, these findings highlight the potential significance of SNORA37 in various pathological conditions and its involvement in cancer-related processes. Further research is needed to fully understand its specific mechanisms and potential therapeutic implications.
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