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hsa-mir-4721: Hsa-mir-4721 is a microRNA precursor that has been studied in various contexts [PMC7566007]. Lentiviral particles carrying the hsa-mir-4721 precursor were used to generate two stably transfected cell lines, HONE1-miR-4721 and SUNE1-miR-4721 [PMC7566007]. Hsa-mir-4721 is one of the miRNAs predicted to interact with the 3' UTR of PCSK9, along with several other miRNAs [PMC5874276]. It has been found to promote the invasion capacity of nasopharyngeal carcinoma cells [PMC10050890]. Hsa-mir-4721 is also upregulated in the skin of patients with postherpetic neuralgia (PHN) compared to controls [PMC8914318]. In the context of hepatic fibrosis, hsa-mir-4721 has been found to have lower accuracy compared to other miRNAs such as miRNA-3162 and miRNA-1225 in indicating hepatic fibrosis [PMC7939739]. It is also differentially expressed between different liver fibrosis stages and can be used as a diagnostic marker for significant liver fibrosis [PMC7939739]. Additionally, hsa-mir-4721 has been identified as one of the miRNAs targeting candidate genes associated with child obesity traits [PMC9092671].
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