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hsa-mir-193a: Hsa-mir-193a is a microRNA that has been found to be significantly upregulated in gestational diabetes mellitus (GDM) patients during the first trimester [PMC9700700]. In studies using INS-1E or primary β-cells, the endogenous activity of miR-193a was inhibited using miRCURY LNA Inhibitor hsa-mir-193a [PMC6009611]. Hsa-mir-193a has also been found to modulate apoptotic processes by promoting CASP3 activation induced by TNFSF10 signaling [PMC3759901]. Additionally, hsa-mir-193a is one of the miRNAs used in calculating risk scores for certain conditions, with its expression level contributing positively to the score [PMC3069027]. Hsa-mir-193a has also been implicated in drug resistance, specifically in cytotoxic resistance genes and endocrine therapy resistance genes [PMC8266326]. In a comparison between patients in remission and control samples, hsa-mir-193a was identified as one of the miRNAs likely to be implicated in relapses [PMC2708922]. Furthermore, hsa-mir-193a expression levels have been observed to steadily increase over a 72-hour period post-infection [PMC3258008].
References:
[PMC9700700] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700700/
[PMC6009611] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009611/
[PMC3759901] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759901/
[PMC3069027] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069027/
[PM8266326] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM8266326/
[PMC2708922] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708922/
[PMC3258008] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258008/
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