hsa-mir-3178: Hsa-mir-3178 is a specific type of miRNA that plays a role in gemcitabine sensitivity in PANC-1-GEM cells [PMC9088115]. Downregulation of RhoB resulted in an increase in the IC50 of PANC-1-GEM cells to gemcitabine, indicating reduced sensitivity to the drug [PMC9088115]. Additionally, downregulation of RhoB antagonized the re-sensitization effect of the hsa-mir-3178 inhibitor on gemcitabine in PANC-1-GEM cells [PMC9088115]. This suggests that RhoB is involved in mediating the effects of hsa-mir-3178 on gemcitabine sensitivity [PMC9088115]. The miRNA qRT-PCR primer sets specific for hsa-mir-3178 were designed and synthesized by RiboBio Inc, indicating that these primers were used to detect and quantify hsa-mir-3178 expression levels [PMC9088115]. Co-transfection experiments confirmed that hsa-miR-3177-5p and hsa-mir-3178 downregulated the chemiluminescence intensity of a specific sequence, further supporting their role in regulating gene expression [PMC6365703]. Overall, these findings highlight the importance of hsa-mir-3178 and its interaction with RhoB in modulating gemcitabine sensitivity in PANC-1-GEM cells [PMC9088115][PMC6365703].