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RNU6-1: RNU6-1, also known as U6, is commonly used as a normalization tool between samples [PMC3262198]. In breast cancer patients without active disease, levels of U6/RNU6-1 and the U6/SNORD44 ratio were found to be elevated in the sera [PMC3262198]. This suggests that U6/RNU6-1 may not be a suitable normalization tool in these cases [PMC3262198]. In early-stage colon carcinoma, circulating extracellular vesicle (EV)-associated miR-125a-3p has been proposed as a diagnostic biomarker for early detection and monitoring of the disease [PMC6429352]. This specific miRNA may serve as a potential biomarker for colon cancer due to its association with EVs [PMC6429352]. These findings highlight the potential of using circulating miRNAs and EVs as diagnostic tools for specific types of cancer, such as breast cancer and colon carcinoma [PMC3262198][PMC6429352].
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