MT-TE: MT-TE is a mitochondrial gene that encodes a transfer RNA (tRNA) for glutamic acid [PMC9294413]. In previous investigations, four tRNA mutations, including MT-TE 14693A > G, have been identified as mutations associated with Leber's hereditary optic neuropathy (LHON) [PMC7687527]. Skeletal muscle biopsies were obtained from patients with mitochondrial diseases caused by pathogenic mitochondrial DNA (mtDNA) variants and nuclear DNA (nDNA) variants. These variants included m.14709T>C MT-TE, which is reported as pathogenic and associated with various syndromes [PMC7501294] [PMC7711282]. In the common tern species, the RefSeq sequence was found to be missing a duplication in the control region (CR) involving several genes including MT-TE [PMC8082918]. CIII deficiency was observed in patients with the m.3243A>G MT-TL1 variant and those with variants in MT-TG, MT-TE, and MT-TW genes [PMC7501294]. In chicken mtDNA, the arrangement of genes is different compared to human mtDNA, with MT-ND6 and MT-TE transposed downstream of MT-ND5 [PMC9739059]. Modifications were found at specific positions of tRNAs including position 14699 of MT-TE [PMC9308231]. Knockout mice showed decreased expression of several mitochondrial tRNAs including mt-Tl1, mt-Tm, and MT-TE [PMC5496330]. Melatonin was found to regulate factors involved in mitochondrial translation and metabolism-related processes such as DAP3, LONP1, MALSU1, MRPL14 along with MT-TE gene expression in granulosa cells [PMC8950389] [PMC6678485].