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Homo sapiens (human) long intergenic non-protein coding RNA 200 (LINC00200) URS00003472D5_9606

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LINC00200: LINC00200 is a long non-coding RNA (lncRNA) that has been identified in various studies as a potential biomarker and therapeutic target in different types of cancer, including hepatocellular carcinoma (HCC), renal clear cell carcinoma (ccRCC), gastric cancer (GC), and kidney renal papillary cell carcinoma (KIRP) [PMC8798454] [PMC7767998] [PMC7396386] [PMC8291889] [PMC7716774] [PMC6794712] [PMC9139553] [PMC9691318]. High expression of LINC00200 has been associated with poor survival outcomes in HCC and KIRP patients, as well as with tumor progression in ccRCC and GC [PMC8798454] [PMC7767998] [PMC9691318]. LINC00200 has also been found to enhance chemoresistance in GC cells to oxaliplatin through the E2F1/RAD51 axis, suggesting its potential role in therapeutic resistance mechanisms [PMC9008104]. Furthermore, LINC00200 has been shown to act as a molecular sponge for miR-143-3p, leading to the upregulation of its target gene PAI-1, which is involved in tumor proliferation and invasion in GC cells [PMC9860977]. Although the specific function and mechanism of LINC00200 are still largely unknown, its dysregulation across different types of cancer suggests its potential importance as a diagnostic marker and therapeutic target for further investigation.

Genome locations

Gene Ontology annotations

Sequence

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GUCGCACGCUUUGCGUAGAUGAGGGAUGACGCAGGCACAGGCCUGAGCGUCGCACGCUUUGCGUAGAUGAGGGAUGGCGCCGGCGCAGGCCUGCGCGCCACGCGCUUUAGGUGGAUGAGGGAUGGCGCAGGUGCAGGCCUGCGCGCCUCACGCUUUAUGUACAUGAGGGAUGAGGCAGCACAGGAAUUGGCACAACCUGAAGUCAGCUCUGCAGCUUUCCAAGCUUCGUUCUGCGUGUCCUGUACUCAACAGUCAUCUCAUGCUGCAGGGUGGCUGCGUGUGCUCCGUACAUCACACCCAUAUUUCAGGGAGAAGACUGCACAUAUAACACAGCUCUGCAUGGAAAACCUUCCGCCUGGAGGGGUGGCUUCCUAGAGGUGUGGCGUUGCCCUCUGUCUUGAACAGGCUGUGAGCCGUUUUGUCAUUUGGGGUUUCUAGAUGCAAACAGCAGAAGCUGCUGGCCAAUUACCAAAGGGAACGUGCUGUUAGGAUAUCAGGGCCUGGGAGCUGCAGCAAUGUGGGCUGACAGCAGAGAGCUAAGGCACUUUCCGAGGUGACGAGCUGGGCUGCUAUGCUGGAGACGGCUGGGCAGAAGCAGUUAGCAGGGCAUUUCCUUGUGUCCUUAUCUCAAGAGUCACAGUUUCAGGAGUGAGCAUCUCAGAGGUCAGGGUUCAUUCACAUGCCACCUCCCUUCUCACUGUGUCAUUGGGGAGGGGCCGUCUGGACCCUCUGGCUCCUGUGGCAAGAAAUGGUCCCAUCAAGUCAUCCAAGGGCCUGGAAGCCUCCCAAGGAAAGCAGGAGGGCUGGGUGCUGAGCAGCGUCCAGCAGCAAAGGUAGGCUCCAGCCCCGCAGGUGUGGCUGCGCCAUCCCAGGGAACGUGCCCCAGCAAGUGCUGGUGCUGCUCUCACUACAGGUGGGGUUGGUUUCACUGGACAGGUGGCACUUCCUCACCUCUUGCCCUCUGGACCCACGGCAGGCACUUUCCAGGGCACAUCACGUGGGUGUGCGGUCUGGCUGCUGGGUCCACGCGGGUUCUCAAUCAUGACCUGGCUUGCAAGCUCUUUCCACAGUUGGAUAAAUGAAGCCGUUGGGGAAGUAUCCGCAAACUCUUACAGUGAGUAUGUGAUAAUGACACACGCGUGGCCCUUCUAAGACCUCCGCUAGGCAUUAUCAGUGACUGUGCUCGUGAGCGCUGACCUCCGCUAGGCGUUAUCAGGGACUGUGCUCGUGAGCGCCGACCUCCGCUAGGCGUUAUCAGGGACUGUGCUCGUGAGCGCGGACCUCCGCUAGGCGAUAUCAGGGACUGUGCUCAUGAGGGCGGACUUUCACCAGCCACGCUUCCGAGGAGUGGAGUCUUUCUCAGCUCUGCCUCUCCAAGAUGACCAUCUUGUGAAGACGAUGCGUUCUUUAUACACAAGUUCUGUGUGUGUGUGUGUGUGUUCCACACACAGGACCAAAGUUGAGAUAGGCGCACAUUUUCUUGGUCCCACUUGUGGCCCCAGUCGGCUGUCAGAAGUGGGUGUGCUCCACAUGUACCCACCAUGUCAGGGCACAGUGCUCACAUUUCACACCUCAGCAGGUGCCUUGAUGUUGACCAGAGGCCCCAAAAUCAUCUCUUUCUAUGACUUCUAGAUCUUAGAUUCCCAGGAACUGGGAAAUGCAGUCAGUAUCUUUUGGGUCCAAGAAACUUUGUCAGAGCCCUUGUGGGAGAACCAUAGAUUCUCACCAGAUAAACAGAAGAGCUUCGUGUUAGAGAAACCCGCCUGUCUCCCCACAUUCUCAGUUUUCUGGAGAGCAGCUGAAAGCCAUCUGGGUGGAGAUUAAGAGCUCCAACCGUGUAGCUUUGAUGUAUCGGGCAAGUUGCUUAAGCUCUUUAAUGCUGUUUCCUCAUUUAUUGUGUGAGGCCAAAAAUACCCAUUCCUUAAAGUUGUGAGGAUUAAAAACAGUAAUGAAAAGUGAGUGGCAAGUGCCGAGUACACAGUCAAGUACCUGAUACUUUUUAGUGUAAGGUAAGUAGCAAGAAAGCAUGAAAUUUAUUUUCAUUUACUCUUACUACAUGUGGUAAACCAUCUAUGCACAGAGCACUGCAUUGGGUGCCAUGAAUGACAGAAUAAGAGUACCAGGUGCAUGAAAAGCUUAAAAGACAAAUGAGACAGAGCUAGGCUGCAGAAGACUUAAAAAGUUGAUGUAUUUAACUUUUAAUGGACACACUGUACAUGUUUAUGGGGUACGAUUUGUUGUUUCCAUGCAUAUCUGUGUUGUGUAAUGAUCCAAUCAGGGUAGUGUGUGUGCCCAUUUCCUCAAGGGUGGAUCAUUAUGUGUAUCAUCGUGCAUCAUCAUGUAUCAUGCAUGUACCAUCAUCAUGCAUCAUUGUGCAUCAUCAUGCCUGUAUCAUUAUGUAUCACCUCAUGCAUAUAUUAUAAUGUAUCACCUC

Taxonomic tree

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Publications