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SNORA19: SNORA19 is a small nucleolar RNA that is classified as a transcription regulator [PMC6993519]. It, along with SNORA81, may affect the viability of cancer cells, specifically high-grade serous ovarian cancer (HGSC) cells [PMC8759569]. In a study analyzing the effects of space travel on gene expression, SNORA19 was found to be significantly increased in astronauts [PMC9267956]. Additionally, SNORA19 has been identified as a potential candidate gene related to Hermansky-Pudlak syndrome (HS) [PMC9726897]. Knocking down SNORA19 has been shown to inhibit cell migration and affect cell invasiveness through changes in rRNA biogenesis [PMC8759569]. Furthermore, the knockdown of SNORA19 has been found to inhibit proliferation and induce apoptosis in ovarian cancer cell lines [PMC8759569].
In summary, SNORA19 is a small nucleolar RNA that functions as a transcription regulator and may play a role in the viability of cancer cells and cell migration. It has also been implicated in space travel-related gene expression changes and Hermansky-Pudlak syndrome. Knocking down SNORA19 affects rRNA biogenesis and inhibits proliferation while inducing apoptosis in ovarian cancer cells.
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