hsa-mir-27b: Hsa-mir-27b is a microRNA that has been implicated in bladder cancer [PMC5342451]. A functional SNP (rs10719 T > C) in the 3′ untranslated region (UTR) of the DROSHA gene has been associated with bladder cancer risk by disrupting the binding of hsa-mir-27b and subsequently affecting DROSHA expression [PMC5342451]. A study involving 66 pairs of tissue samples showed that hsa-mir-27b is downregulated at the mature miRNA level but upregulated at the premature level [PMC9502615]. These findings suggest that hsa-mir-27b may play a role in bladder cancer development and progression [PMC9502615]. The functional SNP in the DROSHA gene may contribute to this by altering the binding of hsa-mir-27b, leading to dysregulation of DROSHA expression [PMC5342451]. The dysregulation of hsa-mir-27b at different stages of maturation may also have implications for bladder cancer pathogenesis [PMC9502615]. Further research is needed to fully understand the mechanisms by which hsa-mir-27b and its interaction with DROSHA contribute to bladder cancer development and progression [PMC5342451]. These findings highlight the importance of studying microRNAs, such as hsa-mir-27b, in order to gain insights into the molecular mechanisms underlying complex diseases like bladder cancer [PMC5342451] [PMC9502615].