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hsa-mir-1303: Hsa-mir-1303 is a microRNA that targets the 5ʹUTR of the SOCS3 mRNA [PMC8527307]. In a study, hsa-mir-1303 was found to be upregulated in 3f-treated hTERT02.3 cells [PMC9598575]. Additionally, hsa-mir-1303 was identified as one of the miRNAs involved in circRNA-miRNA interactions [PMC6085698]. Another study identified a binding site for hsa-mir-1303 in the 3ʹ UTR of the Spcs3 gene [PMC4742137]. Furthermore, hsa-mir-1303 was found to be mutated at a high frequency in both colorectal cancer cell lines and primary tumors [PMC3279428]. The hairpin precursor of hsa-mir-1303 was sequenced to determine the extent of a deletion in each microsatellite instability colorectal cancer cell line [PMC3279428].
In summary, hsa-mir-1303 is a microRNA that targets the 5ʹUTR of SOCS3 mRNA and has been found to be upregulated in certain cell types. It is also involved in circRNA-miRNA interactions and has been identified as having binding sites in other genes. Furthermore, it has been observed to have mutations at high frequency in colorectal cancer cells and tumors. The extent of deletion within its hairpin precursor has also been investigated.
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