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Homo sapiens (human) small nucleolar RNA, H/ACA box 59B secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 59B URS0000329D3E_9606

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SNORA59B: SNORA59B is a non-coding RNA (ncRNA) sequence with a length of 701 bp [PMC8294561]. It has been well-processed by GCFM [PMC8294561]. The host gene of SNORA59B is a protein-coding gene [PMC7011154]. SNORA59B is one of the six snoRNAs (SNORA2, SNORD12B, SNORA59B, SNORA70B, SNORD93, and SNORD116-2) that have been identified as independent risk factors significantly related to survival [PMC7011154]. In a test series, patients in the high-risk group tended to express high levels of risky snoRNAs such as SNORD12B and SNORA70B, while patients in the low-risk group tended to express high levels of protective snoRNAs such as SNORA2 and SNORD116-2 [PMC7011154]. The host gene-associated 5'CpG islands of SNORA59B have been found to be hypermethylated in colorectal cancer cells [PMC7011154]. There is a high correlation between the expression levels of snoRNAs (including SNORA2, SNORD12B, and others) and their corresponding host genes [PMC7011154]. In addition to its role as an independent risk factor for survival in cancer patients, the expression level of protective snoRNA such as SNOAR59B has been found to be higher in low-risk groups compared to high-risk groups [PMC8658237][PMC9524901][PMC10050728][PMC7812721][PM8032227][PM10094766][PM9524901][PM9524901]. [200 words]

Genome locations

Gene Ontology annotations

Sequence

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AACAUAGAGUACACAUUUUCUGUUUUGUUUAAGAAUUAUUCUCUUGCAGACCUAUGUUUUUUGUUUUUGUUUUUCUAUCCUUGGCAGAGUUUUUUAACAUGGAUUUUUUACUUCACUUUUAAUAUUUUAUUUACAUUUUAUAUUUGAGUAAAUUCAUUAACUAUAUCUAAGUCAAAAUGCUUAAUGGUAUAUAGGAUUCCACUAUAUGUGAUAUACUUUUAAAAUCAAUUUCCUAUGGUUGAAUAGUUUAUUUCCAAUGUUUCAAUAUUAACAACUCUUCAAGGAACAUCCUAGGAAAAAAUAUCUUCAUAUACUUGUCUGAUUAUUUCUUUAAGAUUCAUAAAAGUGGGCCCAGGGUAUGUUCACGGGGCGAUGCUGCCCUCCCAGCUGGCCCAUGGGUGACCCUGGGAACAUUAACUGCCUCACAACGUUUGUGCCUCAGUUACCCGUAGAUGUAGUGAGGGUAACAAUACUUACUCUCGUUGGUGAUAAGGAACAGCUAACACAACACACAGGGUUUUUCUGCUCCCAAAAUGGGAUUCUUCAGUGCACCAAAUCGAAGAAAGCACUGGAGCUCACGCUGGUUUCUCCAUUGUUUCUCCUUAACAGUGGAAACUGUAACUUUUGUUCUAGUAGCAUCUAGCAUGCUCAAUAAUUAUUUGUAAAUAAAAGUUAUACUUUCCCUCCAAAAAAAAAAAAAA

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2D structure Publications