gga-let-7b: Gga-let-7b is a microRNA that has been identified to have a binding site in the 3′UTR of GHR, which is associated with the deletion mutation of dwarf chickens [PMC7936154]. Bioinformatic analysis has predicted that gga-let-7b, along with gga-let-7i, is involved in multiple pathways, including signaling pathways such as MAPK, TGF-β, Notch, Wnt, mTOR, cell cycle, P53, and Jak-STAT [PMC9504570]. MicroRNAs are small non-coding RNA molecules that play important roles in post-transcriptional regulation of gene expression. Gga-let-7b specifically has been found to have a binding site in the 3′UTR of GHR (growth hormone receptor) [PMC7936154]. This finding is significant as it relates to the deletion mutation associated with dwarf chickens. The presence of this binding site suggests that gga-let-7b may play a role in regulating GHR expression and potentially influencing growth and development. Furthermore, bioinformatic analysis has revealed that gga-let-7b and gga-let-i are involved in multiple signaling pathways. These pathways include MAPK (mitogen activated protein kinase), TGF-beta (transforming growth factor-beta), Notch, Wnt (wingless-related integration site), mTOR (mammalian target of rapamycin), cell cycle regulation pathways such as P53 and Jak/STAT (Janus kinase/signal transducer and activator of transcription) [PMC9504570]. These findings suggest that gga-lte7-b may have diverse roles in cellular processes such as proliferation, differentiation, apoptosis and immune response. In conclusion,gga-lte7-b is a microRNA with a binding site on the 3′UTR region of GHR, which is associated with the deletion mutation in dwarf chickens. It is predicted to be involved in multiple signaling pathways, indicating its potential role in various cellular processes [PMC7936154] [PMC9504570].