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Homo sapiens (human) ARAP1 antisense RNA 2 (ARAP1-AS2) URS000030B95E_9606

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ARAP1-AS2: ARAP1-AS2 is a non-coding RNA located on chromosome 11 [PMC6336695]. It has been reported to be related to the pathogenesis of diabetic nephropathy (DN) [PMC8435884]. In patients with diabetes, ARAP1-AS2 was found to be downregulated compared to the control group [PMC9068318]. ARAP1-AS2 has been implicated in high glucose-induced renal proximal tubular cell injury and diabetic renal fibrosis [PMC8971206] [PMC8200121]. It has also been associated with asthma and rheumatoid arthritis (RA) [PMC8277837] [PMC8971206]. ARAP1-AS2 interacts with ARAP1 and promotes its expression, leading to persistent activation of EGFR and activation of the EGFR/TGF-β/Smad3 pathway in high glucose conditions [PMC9974832]. YY1 is a transcription factor that positively regulates the transcriptional activity of ARAP1-AS2 in high glucose-induced human renal mesangial cells (HRMCs) [PMC9974832]. The upregulation of YY1, ARAP1-AS2, and ARAP1 promotes kidney fibrosis by inducing HIF-α accumulation, aberrant glycolysis, and ECM accumulation through the EGFR/PKM2/HIF-α pathway in DKD [PMC9974832]. References: [PMC6336695] [PMC8435884] [PMC9068318] [PMC8971206] [PMC8200121] [PM9974832]

Genome locations

Gene Ontology annotations

Sequence

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AAUGUGUCCUCAGGCCUGUCCCCGCAGGUGGGCUCCCUCCAGGAGCACCAGCUCUGCCUGAGUCAUCCUUCAUUCUGCAGGAUUCAGAAGCAACCGGACGGGGUGCAGGAGACUGAGGAAUUGGGAGAGAGACAGACAGAUGCUGGGGAUGUGCCCUUGGCCCAAGGGUCAGGCCUGGCUCCUCCCUGCAUGGCCAGAACUUUUCACAUGGCUUAGGCAGGGCCCUUCUGCCCUCCAAACAUCAGUUUCCCCAUAUGCCAAGACAUCUCCCUGAGCUGGUAGAUGAGAUGGGUUAAGACAGCAUGAGGAACAGGGCAGCAGAAAGACGGGGGUGGUCCCAAGGGGCCCCAGAGCUGCAGUGCCCUGACCUUGUCCAGCUCCUCCUGGUUGCCAAAGAGCGGGUGGUAGCGGCGGUACUUGCCCUCACGGUACUUGGCCUCCAGGUGGCACCGCCGGGUGCUGGGGCUGCUGCUGGGCUGCAGGGCCUCACUGGGGGGCACGUUGGCUGCCCAGAAGCGGUUCCCAGCGCCAUUCCCCAGCUGUAAGAAGAGCUGUGGGGGUGUGCAGGAGGUCAGACGGGCCAGCUGACAGCCAGGGGCCGUGCCGGGCAGAAACUUGGUUUCUGAGGUUGUUAGGAAAGGGGCUGGGAGAGCCAGGCCAUCUGCCCACUUUCCCAAUGGGGAAGGUGAGGACAGCCUGGCCUGCUGGUGGCUGGGGAUGCUCCUGCCACCAGCACUGGGCUCUGAGCCUAGGUCUCAGGCUCAGUGACAGGACAGGGAGUCAGCAGACUGACAGGUGGAUGCCUCAGGCCUUGCACCUGGUCCCAGGGGCCUUGCUGCUGCCCCACCCAGUUCCACAUCUGGAGCUCUGCAUUCCUGAGGCUGUGACAGCUGGGGAUGGGUGCCUAACCUGUCAGCCAAUGGGGUGGGCAGGGAUUUUGGAAACCUCUCCUAUCCCUGACAUUCCUCUCUGGGCAAGAGGGAUGGGGGUGGAUUCUGGGUGAGUGCAGGGAUCCAGCAUUUGGUAAUCAGUUCCUUCAUUCGGCUCCUCAUUCCACAGCCAUUUCCUAGGCCCCCCACCUUGCCUCCUUGUCAGGUCCUGUAUGGGGUGCUGGAGUCACAGCACAGAACAAAGCAGAAAAGUCCUUGCCACUACUGAUUCACUCUGUGUCUUCCAGCAAGUUAUUUUCUCUCCCUGGGCUUCAAGGCUGUAAACUGGUUAUUCUAAUCCUAACUCCUGGCUUGUUCUGAAAGUCAGUUAAUUAACAUAUGCAAAGUCCUUAGCACUUAUGUGCCAAACACACCGUGGGGAGGUGAGAAACGGAUGUGACACUCCAAGUGUCUGGAGUCUGCAGCCUGGGUCUACCCUCCCAUUGCAGGUUCUCCCCUAUAUCUACCACAUAUGGGUACCUGGGAGUUUCCAGUACAGGGGCAUAAAUGUACACGUGUGUGCACACACAGCACACAUAUAUAUACCCACUGGUACAUGUGAGUUCACAUGAAAUGGAGGCUGAGGGCCUCUGAGGGGCUGUGCAAGGUAGGGGAGAAGGCCCUGGGUCAGCCAGAAGUGGGAUGGAAAGAGGCAGGGAUGGUGGUCAAUAUGCAUUUACAGGGUAAUCUCAGGCAGAUUACAGCCCUGCCCAGGACCUCAGUUUACACAUCUAUUCAAUGGAUGACAGUGAAAUUAGAUCAGAAGUUAGCAAAUUCUUUCUCUAAAGGGCGAAAUAGUAAUUAUUUUCGGCUUUACAGAACACAUACAGUCUCUGCUGCAUUUUCUUCCUUUUUUUUUCUUUAAAAAAAAAUAACACUUUACAACUAUAAAAAC

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