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hsa-mir-744: Hsa-mir-744 is a mature microRNA that has been shown to be highly expressed in cell lines Rn5-1 and Rn5-20 [PMC7139524]. Increased expression of hsa-mir-744 has also been associated with chemo-resistance in breast cancer patients [PMC9469592]. The differential expression of hsa-mir-744 is not simply a recapitulation of mRNA classification, as it is intronic in the MAP2K4 gene, which plays a role in mRNA subtype classification [PMC3043070]. Functional studies have confirmed that up-regulation of hsa-mir-744 leads to decreased expression of PELI3 [PMC8230573]. Hsa-mir-744 is one of the overexpressed IR-responsive miRNAs that have been found to be deregulated in human cancers [PMC3275573].
TaqMan miRNA primer assays have been used to validate the expression levels of various miRNAs, including hsa-mir-744, in qPCR experiments [PMC9469592]. Hsa-mir-744 has also been found to be associated with TMED2/3/4/9 and other related miRNAs in an interaction network visualized by Cytoscape [PMC9816852].
In a comprehensive study, an 8-miRNA signature with high statistical significance was identified for colorectal cancer patients, which included hsa-mir-744 as one of the prognostic markers [PMC8299930].
Overall, hsa-mir-744 has shown differential expression patterns and functional implications in various cancers, making it a potential target for further research and clinical applications.
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