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SNORD1A: SNORD1A is a C/D box snoRNA that has been implicated in various aspects of leukemia and lymphoma. Dysregulated snoRNAs, including SNORD1A, have been associated with shorter progression-free survival in chronic lymphocytic leukemia (CLL) patients [PMC8975097]. SNORD1A has also been found to play a crucial role in the progression of diffuse large B-cell lymphoma (DLBCL) by influencing ribosomal and mitochondrial processes [PMC9939161]. The expression levels of SNORD1A have been evaluated in samples using quantitative real-time PCR, showing a good correspondence with other techniques [PMC3766210]. Risk models for different cohorts have been established, including SNORD1A as one of the factors [PMC9939161]. In addition to its role as a snoRNA, SNORD1A is hosted by the Small Nucleolar RNA Host Gene 16 (SNHG16) on the 17q.25.1 region [PMC9598326]. The mutations of genes co-expressed with SNORD1A have also been analyzed using the R package "maftools" [PMC9939161]. Overall, these findings highlight the importance of SNORD1A in leukemia and lymphoma and suggest its potential as a therapeutic target.
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