v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) WWTR1 antisense RNA 1 (WWTR1-AS1) URS00002DAAC2_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

WWTR1-AS1: WWTR1-AS1 is an antisense long non-coding RNA (lncRNA) that is increased in head and neck squamous cell carcinoma (HNSCC) and is positively correlated with HNSCC cells [PMC9490863]. Inhibition of the antisense lncRNA ZEB2-AS1 impairs the stability of ZEB2 mRNA [PMC8717422]. Aberrant upregulation of WWTR1-AS1 is associated with malignant features and unfavorable prognosis in HNSCC by modulating WWTR1 mRNA stability [PMC8717422]. WWTR1-AS1 has also been identified as a potential lncRNA associated with glioblastoma multiforme (GBM) progression [PMC7831882]. Knockdown of WWTR1-AS1 reduces TAZ expression and increases apoptosis in head-neck squamous cell carcinoma [PMC8164607]. WWTR1-AS1 is among the lncRNAs related to overall survival in ovarian cancer (OC) and has binding sites with EIF4A3 [PMC7272521]. Treatment with ivermectin leads to changes in the expression of WWTR1-AS1 in OC cells [PMC7272521]. A study reported a significant correlation between higher expression levels of WWTR1-AS1 and larger tumor size, cervical node metastasis, and poor prognosis in head-neck squamous cell carcinoma [PMC8650115].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
CUGGGUAAGAGGAGACGGGUGCCCCCCACCCACUCCUCCCGGCCGCGCGGACCUCUCCCGCUCAGACCUGCAUCUGCAUUCCUUUGAGUUUACCACGGACUUGGGGCGGGAUCAAAGGGAAAGUGGCCUGAGCCUGUUUCAUCAAGGGGUUGUGGACCGAAACCAAGGCCGGGGGUGGCGGAGGGCACGCGGAUGAGGGGCUCAGGCCUAGGAAGGGCCGGUCCUGGACACCGCGCCCUCCCCUGCAGCCAGGCGCCGAGGCCUGCAGCACCCGGAGCGCCGCACUGACCCGCGAUUCUGCCCGAAGGCCGGCCCGGGUGCGCCCCGGCGCGGGGAGACACCAACAAGGCCAGCUUUUCCACGAGAGGCUGCUUAGCUCUUGUGACCAUAUUUGGUCUGGCGAGGAGGCAUCUUGGCUGCCUGGCUCUCAAUUGUCUGCUAGAGCACAGACGGUGCCCAGAAAGUGCCUCUGUCACUGGAGAUGCGGCUUCGCCAACGGGCUUGAGUGCAAUAGCUCCAUCUCAGCUCACUGCAACCUCCGCCUCCCGGGUUCAAACGAUUCUCCUGCCUCUGCCUCCCAAGUAGCUAGGAUUAAGACGCCUGCCACCACGCCCAGCUAAUUUUUGUAUUUUUUAAAAGCAAAAAUGGGGUUUCACCAUGUUGGCCAGGCUGGUCUCAAAUCCUGACUUCAGGUGAUCCGCCCGCCUCAGGCUCCCAAAGUGCUGGGAUUACAGGCAUGAGCCACCGCGCCCAGCCUGCCUUAAUAUUUUUACAGGGUAAAAUAAAGUCGAAGUUAAAAUCUGGAGCUGCCUUGGAGGAGAAAAGUUUAAGGAAAAGACAAGGCCACUCAUAGUUUUGCCUCGGAAAAGGUAGAAUUUUGGGGCCACUCCCUGAAUGGCUGCAUCCAUAUCCAAAACAGAACCACCAAAGUGAGCCACUUCCCCUGUUAUCUGUACUUGGAGGUGGCUCCAAUUCCAGACUCCUCAUAGACUGGAAGAAAUUAGGGCCAUCUUAGACUAAGGCAGGCAUACACGUAUCAUCCUUUUUUUUUUUUUUUUGAGAUGGAGUCUCACUCUAUUGCCCAGGAUGGAGUGCAGUGGCAUGAUCGCGGCUCACUGCAACCUCUGCCUCCCUGGUUCAAGCAAUUAUCCUGCCUCAGCCUCCCGAGUAGCUGGGAUUCUGUGCAGCAAGUCCUCUGCCCAUAGGACUGGCAAAAGGAAAGGGGAAACUAGCACAGGUCACUCCUUGGAAAGUAGAAUCUUUGCAAGCUACUCUCAGAAGCCAUCACAGUUGCAACAACAGGGGAAAUAAGCUAUCGAACAAGAGGAAGUGACUGGAACCUAAUGAUACUAAUUCAGAAGUCACAAGGCUGACUUGAUGAUUAAAAGAUGAAAACUUGAGGCCAGCCCUACUCUAGGAAAGUCCUCACUCCCGAAGAAAGGAGACCUGAGCCACUAAGUAAGAAGUCCAGUUACCCUGUUGGAUAAACCACAUGGAGAAGGAAAGGCCCUGAGAUACUUGGAGAGAGGGAAAAGUCCAGCUGCCCAGCACCUGAGCUGAGCCCAGCCUCAGCCAACCCCACCGGCUGACUGCAAACACAUCAGUGACCACCAGUAAGACCAGCAGAGCUGCACAGCCAAGCCCAGCCCAGAUUGCAGAAUUGUGAGCAAAUAAAAUGGAUAUUGCUUUAAGCCACAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications