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MIR92A1: Investigating the locus revealed that the miR17-92 cluster, which includes MIR17, MIR18A, MIR19A, MIR20A, MIR19B1, and MIR92A1, is affected by copy gains or amplifications [PMC9259584]. In Alzheimer's disease (AD), MIR199A2, MIR218-2, MIR24-2, MIR92A1, and MIR99A were found to be upregulated, while MIR129-2, MIR1296, MIR219A1, MIR29B1, MIR375, MIR411, and MIR431 were downregulated [PMC7564652]. The targets of MIR199A2, MIR219A1, MIR24-2, MIR375, MIR411, and MIR92A1 are known, but their role in AD is not clear [PMC7564652]. Dysregulation of several miRNAs, including MIR29B1, MIR129-2, MIR219A1, MIR199A2, MIR92A1, and MIR1296, has been observed in AD patients [PMC7564653][PMC632161][PMC400563][PMC959924]. The miR17-92 cluster has been found to be upregulated in both medaka and human melanoma models [PMC6321611]. A microduplication at 13q31.3 was detected, which encompassed the miR-17 ~ 92 cluster genes and the first five exons of the GPC5 gene [PMC4005632]. A p53 binding site in the human MIR92A1 locus was also identified [PMC9207587].
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