Homo sapiens (human) hsa-miR-147a
URS00002849B7_9606
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hsa-mir-147a: Hsa-mir-147a is a microRNA (miRNA) that has been studied in relation to lung neoplasms [PMC6449885]. In a recent study, 12 hub miRNAs, including hsa-mir-147a, and 15 hub miRNA sponges were identified [PMC7591752]. Additionally, several miRNAs targeting specific genes were identified, including hsa-mir-147a targeting CDKN2A [PMC9981365]. However, in the analysis of miRCancer, dbDEMC, and PhenomiR databases, hsa-mir-147a was not confirmed [PMC6449885]. In the regulatory network analysis of CGs (Cancer Genes), several transcription factors (TFs) and miRNAs were identified as regulators of CGs. Hsa-mir-147a was one of the miRNAs identified as a post-transcriptional regulator [PMC10000172].
References:
- [PMC7521494]: Primer sequences were as follows: hsa_circ_0072995 (5’- AGAACAGCTATGCCCTCCAG-3’, 3’-CCCATCTCATAGCCAGGTGT-5’), hsa-mir-147a (5’-GCGGGCGTGTGTGAAATGC-3’, 3’-ATCCAGTGCAGGGTCCGAGG-5’), and CDK6 (5’CCGTGGATCTCTGGAGTGTT3’, 3’GGTTGGGCAGATTTTGAATG5’)
[PMC7521494]
-[PMC6449885]: A recent study showed that hsa-mir-147a is related to lung neoplasms. Among these miRNAs, 48 miRNAs were confirmed in miRCancer, dbDEMC, and PhenomiR databases, and only two miRNAs (hsa-mir-520 g, hsa-mir-147a) were not confirmed.
[PMC6449885]
-[PMC7591752]: In this work, we have identified 12 hub miRNAs (hsa-miR-195-5p, hsa-miR-15a-5p, hsa-miR-26b-5p, hsa-miR-23a-3p, hsa-miR-93-5p, hsa-miR-2103p,
hsa-miR25 3p,
hsa miR30b 5p,
hsami R148b 3p,
hsami R149 5 p,
hsami R200c 3 p and
hsamir147 a) and
15 hub miRNA sponges (SLC38A2,
SHOC2,
DDX6,
WSB1,
PURB,
DDX5
DLEU2
USP15
C6orf62
ADAM10
STK4
LBR PNISR ANKRD44 SERINC1).
[PMC7591752]
-[PMC9981365]: Subsequently, 110 miRNAs targeting IGF2 including hsa let7 a 5 p hsamir125b 5 p hsamir9 3 p
83 miRNAs targeting EGFR including hsamir27 a
3 p hsamir30 a
and hsamir7
and so on were identified. Among these miRNAs targeting specific genes were identified including hsamir147 a targeting CDKN2A.
[PMC9981365]
-[PMC10000172]: The CGs regulatory network analysis detected some essential TFs proteins (NFIC, FOXC1, YY1, and GATA2) and miRNAs (hsa-mir-147a, hsa-mir-129-2-3p, hsa-mir-124-3p, hsa-mir-34a-5p, hsa-mir-23b-3p, and hsa-mir16 5 p) as the transcriptional and post-transcriptional regulators of CGs.
[PMC10000172]
mRNA interactions
2 total
Genome locations
Gene Ontology annotations
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Sequence
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GUGUGUGGAAAUGCUUCUGC
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This sequence is found in 5 other species
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