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hsa-mir-302c: Hsa-mir-302c is a microRNA that has been predicted to bind to the rs10204525 polymorphic site in the 3' UTR of PD1 mRNA with allele G, according to bioinformatics analysis [PMC4662465]. It is part of a group of microRNAs that act together to regulate the expression of specific genes, such as ETS1, ESR1, and MYC [PMC6176299]. In various studies, hsa-mir-302c has been found to be upregulated in different contexts [PMC4268797]. For example, it was upregulated in hepatocellular carcinoma and acted as a tumor suppressor by inhibiting angiogenesis [PMC4434893]. It was also found to be highly expressed in two iPSC-RPE cell lines compared to hfRPE cells [PMC5070511]. In colon cancer cells, hsa-mir-302c was downregulated compared to normal cells [PMC9941246]. Additionally, hsa-mir-302c was identified as a differentially expressed miRNA in atrial fibrillation and myocardial infarction groups [PMC8629660]. In various experiments, hsa-mir-302c has been manipulated using miRNA mimics or short hairpin structures against its gene [PMC9497224]. For example, it was overexpressed using a short hairpin structure against its gene in lentiviral vectors [PMC4100019], and its expression was downregulated by H2O2 treatment [PMC6884596]. Overall, hsa-mir-302c plays diverse roles in different biological contexts [PMC6884596].
mRNA interactions
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