SCARNA2: SCARNA2 is a small Cajal body-specific RNA (scaRNA) that is involved in regulating DNA-PK activation [PMC8866460]. In the absence of SCARNA2, an abnormal DNA-PK complex is formed, which also contains elevated amounts of LINP1, a long non-coding RNA (lncRNA) that facilitates interaction between Ku80 and DNA-PKcs [PMC8866460]. SCARNA2 is upregulated in colorectal cancer (CRC) and is associated with poor prognosis [PMC9490904]. Among the 11 candidates studied, SCARNA2 was expressed in endothelial cells [PMC9630315]. The 3' region of SCARNA2 has been previously studied for its role in the formation of full-length SCARNA2 [PMC7648615]. The efficiency of the non-homologous end joining (NHEJ) repair process was enhanced in cells lacking SCARNA2, indicating its role in regulating this repair pathway [PMC8866460]. Processing assays with purified coilin showed that scaRNA 2 and 9 generate processed fragments when incubated with coilin [PMC4395269]. RRM2 was found to be essential for TDP-43 binding to scaRNA9 and contributed to some extent to binding to SCARNA2 or SCARNA28, but had almost no contribution to binding scaRNA7 [PMC6412121]. The 161 bp region upstream of mature SCARNA2 contains sufficient information for Pol II transcription of the gene, while the mature 3' end has been mapped to position +420 of the gene [PMC2811027].