v24

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Homo sapiens (human) family with sequence similarity 215 member B (FAM215B) URS0000234DB3_9606

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FAM215B: FAM215B is an upregulated long non-coding RNA (lncRNA) [PMC9259367]. It competes with other lncRNAs, including AC104024, AC084082, AC083843, FAM182A, AC022819, AP000525, TTTY10, and ZNF346-IT1 for binding to hsa-miR-139-5P [PMC9259367]. FAM215B is upregulated in CD4+ T cells in responding patients and is associated with brain volume development [PMC8108662] [PMC9520794]. In a gene-based association analysis of the original UKB GWAS study, FAM215B was not significantly associated with total brain volume (TBV) [PMC9520794]. However, nine out of the ten genes (excluding FAM215B) associated with TBV were significantly associated with TBV in the gene-based association analysis of the original UKB GWAS study [PMC9520794]. FAM215B is a new gene that has not been extensively studied before and may be a potential target for knockout experiments in mice to further understand its function [PMC9520794]. Additionally, FAM215B is one of ten genes (SPPL2C, PLEKHM1, NSF, MAPT, LRRC37A2,KANSL1 , FOXO3 ,FAM215B ,CRHR1 ,ARL17A) that may contribute to brain volumetric measures and have associations with cognitive and mental health traits [PMC9520794].

Genome locations

Gene Ontology annotations

Sequence

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UUUCUGUAGAGCCGGCGUUUUGCCCUGUUGCCCAGGAGUUUUUCCUUUAAUGUUCUCCUGCUACUUACUAAUUCACUUUGUCACCCUGUGAGCUCAUAAGAGCAGAGAGAUAGCAACAGGAGCUAAAAAAACUCUAAGCUGUGAAAAAAUAUUAAAUAUGAAAUCAUGAUAGCUAUUAGCUUAAUUUGUUUUAGGCAAAUUGCAAAGUAAUUUUUUGGGAAUCAGUGUCCCACUGCAGUGAUUCCAUAUGGGGAUUCCUAAUUCCCAGUAUGUUUUUAAAAUAAUUUGUAAACACCUAGUACAAACGCAUGAUAUGAAAUUCAAGAGGUGGGAGGAUCACCUGAGCCCAGGAGGUUGAGACUUGCAGUGAGCUGAGUUCACACCACUGCACUCGAGCCUUGAUGACAGAAUGAGACUGUCUCAAAAAAAAAAAAAAAAAAAAAUUGUCCUUAAGUCCAUGUGGACCCCUGACUAGGUUUGUGCCCUAGACAGCCUUCCUCUGAGGGCAGUUCAGGUGGUGAGACUCCAGCUUUAAAUGGCCUCUAGAGAAAUUUCACUAACCUGCCUUGGUGUUUGACCCUGUAUAACCCCUUUCUUCUGGAGGUCCCUUUGGGUGGCAGUAGAUACGGGAUUUGGUGUCUGACAGCUCUGGGGACAGAUCCCAGCUCCAAAUGGCAGAGUCUCUACAGAUUACAAGCCAAAUACUUAGCACUAUGUGCUGAUCUUCAGGAAGUCAGUCUAUAUUUCAUAACAAGUCACAUGGGGAUAAUGAAGGAAUGGCCUAAAAUGCUCUCAGUAAUAUUCCUGAGUCAUCCCUCAGGGCUAGGCUUGGUGUUAGGCAUGGCGGGGAAGGGAGCAGAGCUGUGUGCAGAGGAAGAUGCAGUUCUUGCCUUGUCAGGGUCCCUGACCUGAUGGCGACCCAUGGUGGAGUCUUCAUAGUGACAGACACCACUGUAAAAGCAGAUCCAGGUUGUGCAACCCUCAAAGCAGGUCUCCUCACUCACCGGGAUAGAUAGACUAUUGGCCGUACCUGCAUCCACCGCUUGCCAUGGUUUCGUUGUGGGUGGAGGAUACUUUCCUGUCCCCUGGCUUUGGGUUUGCCCACGUGGCUUGCUCUGGCCUUGGAAUGAAGCAGAAACGAAAGGCUGCCAGUUCCGAGCCCACGUCUGAAGUCGCCUUAGGUGGUUCCGCGGGCCCCGUGCGCUCCCACCUUCACCCAGAGGGCCUUCUCUGGUGCAGCCGCUGCUUCUUCAGCCUCCGCCCAAAAGGAACGGAGCCCCCUGGCCGAUCCGCAGGCCUACAGGGAGCCACAGAGCGCAGCGGCUGGACCAGCGUUCAAGCCCAAGCACAGGCCUGCGAGAACCUUGUUCCAGCCGCCGUUUAGGAUGGUUGAUUAGGACGCGUUGCAGUGGCGGUAGCUCACCAAUCCAGUGCGUGCACCCGCUCCUUUAUUAGGCUAUAGAGCCAGUGGCUCCCACAGGGACCUGAUACAACAGUGCGUUAAAUAAGGAGCAUAUUGAGCUCUCAUGUCGUAAGCCAGUGGAGAAGUCCAGGGCUAGUGUGGGGGCUCCGGCGGGGGCUGUGGCCCCCAUCCGCAUGGAGCCUCCCCAUGGUUCACAGGUCUCAGUCUUCGGAGCCUUCGGCCCUGCGAGCCCGAACGGUCCACAGGGCGGCGCCAGACCCUCUUUCGAACGCCAUCCUCUAAAGCCUCGGCUCCAACCGGUUCCACUUCUUCAGGCUCAGGAUUUUCACUCUUCUCGAAUGGGGGUGGCCCUCCCCCAAUCUUCUGAGUCGCAACAGCAUCUCCCUCCCUCCAGGACCUCAGAGCCAGAGCUGGGCGAGAGGCCCUGACCUCCGGGGUAGGGUGGAAGCGUCCCUGUGAAGGUGCAGUCCUGCCUCCCAUCCCCAGGCGCCGGGCCUCUCCCACCCUCAGCGCCCUGCUCACCUCCAGCUGAAGAUGCCAGGGCACCUCUGCUUCCUCCCUGCCCUCUCUGCAGUACCGCCGAGUGUGCAUAAAAGGGUUUAAUAUAGGCUUUGCCGGGCGCGGGGACUCCCACCUGUAAUCCCAGUACGUUGAGAGACCAAGGCGGGAGGAUCACUUGAGGCCAGGAGUUCAAAACCAGCCUGGGCAACAAAGUGAGGCCCGUCUCUGAAAAAAAAAAAAAAAAAAAAAAAAGAAUAAA

Taxonomic tree

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Publications