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Homo sapiens (human) WEE2 antisense RNA 1 (WEE2-AS1) URS000022CFA6_9606

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WEE2-AS1: WEE2-AS1 is a long non-coding RNA (lncRNA) that is consistently upregulated in glioma cells and tissues compared to normal cells and tissues [PMC9901081]. It has been found to interact with MOB1A and regulate its protein expression level [PMC9485119]. WEE2-AS1 has been shown to have an oncogenic role in hepatocellular carcinoma and triple negative breast cancer [PMC7962937]. Overexpression of WEE2-AS1 is associated with hepatic vascular invasion, poor tumor differentiation, and poor prognosis [PMC8636595]. The stability of WEE2-AS1 is influenced by METTL3, with knockdown of METTL3 resulting in a significantly shorter half-life of WEE2-AS1 [PMC9475453]. GBM samples with high expression of both WEE2-AS1 and RPN2 are significantly enriched in the AKT signaling pathway [PMC9475453]. Higher levels of sEVs (small extracellular vesicles) containing WEE2-AS1 are associated with poorer overall survival and disease-free survival [PMC9485119]. Additionally, WEE2-AS1 may be involved in the modulation of temozolomide resistance in GBM [PMC7962937]. In summary, WEE2-AS1 is an upregulated lncRNA that plays a role in glioma development. It interacts with MOB1A, has oncogenic properties in hepatocellular carcinoma and triple negative breast cancer, and its overexpression is associated with poor prognosis. The stability of WEE2-AS1 is influenced by METTL3. Its high expression along with RPN2 indicates enrichment in the AKT signaling pathway. Higher levels of sEVs containing WEE2-AS1 are linked to poorer survival outcomes. Furthermore, it may be involved in temozolomide resistance in GBM. [PMC9901081] [PMC9485119] [PMC7962937] [PMC8636595] [PMC9475453].

Genome locations

Gene Ontology annotations

Sequence

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GUGCGCGGGCGGAUGGAUCAACGCCGCCAAGUGGGUAAGGUCUGAGGAUUGCGUCAUUAGGCGAUUUUGUUGCUGUACGAACACCACAGAAUGUACUUUGACGACCUAGAUGGUGGAGCCUGGACACACCUCGGCUCUGUGGUGUGGCCUGCUGCUUCCAGGCUGCAAACCUGACAGCAUGGGGCUGUACUGAAUACCGCAGACCAUUGUAAUUCAUGGGGAAAGCGCGAAUGCAGUCCCCCACUACAACAAAUUAUGCAGUCGAGUUUUCCACAUUUGGGAAUAUCACAGGGGUCAGCACAUCCGGAGUGCAAUCGAUGAGCCCCACGCUGGGAAAAACCACCUUCGUGAUCAUGGUAUCUUCCCUGCCAGGGAAGGCCGGAGAACUGUAUUUCUGGCCAGAGCUGCUGCAGAAGGUCUCUGUUCGGCAUCAGGUUGGAUCAUGUUCUGAUGAUAUAGGACCAAGAGGAAAGAAACAGAAGCUUCACUAUUGGGAAAAAUCUUCCCAUUCAAGCCAACUCCAACCCAGCUUCUCCUGGUGGAUUUUAGAGAAACCAAUCAGCUUCAUUUUCAACUUCUUCUAUGACUCCAGAGGAUUCACUUUGCAUCUUGUGACAAAUGAAUAUAUUACCUGAAAAAAAAAUGACAGGAUAGAUAUUGAAGAAAUAAUUUUUUAUAGGACUCUGGAGUGAAGGGAUUAAUAUUGACCAGAGCCAAUGAGGUCAUCUCAUCCUUGAGGGGAGCAGGUGUGAGCUUCAAAUGCUUAGGGCCUCUGGAAGGAAGCUUCCCUGUUGGAGAAAUCACCAACCGGCUCAGCAUGGUCUGAAUGAGGAUGACAAAAGGAGUUGCUGCACAGGGGGAAAGCGAAGUUCCCAGGAGUAAGAUGUGCAAGAAGCGGGCAGCCUUGCAUCUCAGGGCUGAGUUCCCUCAACUGUGUGCUUGAGGGAAGUUCUCCCCUUGCAGACACACUGCUGAGUGAUAAGGAAGCACCUAGACUCCACUCUGACCAGACUUGGUUCUGAGGCCUAUGAAAUGUUGAUGGGAAGAACAGAAGCAGGAAAAUCUAUCUAUUCAAAUUUGCAAGACGUGGAAACUUUUAUUCACCUUCCUGGUUAGACUGUUCCUUUGUCAAAGUAAAGCUAAGGCCAUGGAAAAUGAGCUAUUUGAGAGUUUGUCGCUCCAAGGAAGAACAUGCUGGCCUAAUUGUCCCCCAAGUCAGGAGAGAGAAUUGUAAAAAACACUUAAACAGGCCUAAGUAAAGGUCCAGCACAUUAUUUAUUUAAGACUGAAUUAGAACUGAGUCAUUCCGACUCUGAAAAAAGAGUGUUGUUGGAUUCUUAUGUAUUUAAUGGGUCUGCCCUAUUGAAAACCAUUGUGAAGUAUGGUUUCCCAAGCAAGAAAUGACACUUUCACUGUCAGUCUUUCUAGGAGUCUGGCAGAAUCCAGGACCGGGAUUACCCUUAUUUAUGAAGCGACCUUAGACUAACAGUGGCUCUCUGGGUCUCCAGACAAUUGGCCAGGGACUCUAAAAACCAGAAACAAAGUUGAGAGAACUCCAUGCUGGUGGAGAAAAACAGCUGGCCUUUAUCACCAGAAUGUGCCCCAUAGAAGCAGCAAAGCAGCAAGCGACGUUCUUAAACAAGGGCCUGUGGGCCUCGUCAAGAUCUGGAGGAAUCAUCUACGACUCACUGCUGAGUGAGAGGGCUAGGCAGUGUCUUUAAGGUCCUGCCAGCUUUAACAUUGUAUGCUUUUUCUUUUGUUCAAUCUCUCACCACAACUGGAAGUGUUGCCUCAACUACACAGGAGAAAGUUUGCAGUAACUUAGAGAAAACAUUAUUUUAAUCACCAGUGUAUGUUCUCCUGCUCCCUGGACAAAUCCAUCAGCAGCGGCAACACUGACCAGGUCCAGAUUGGGGCCGCUGCGGUGGAUGUGAAUCCAUUGAAACUAGGGGUCUCCAGUGCUCCUGACUCCUCACAGCUCUGUUCCUAUGACAAGGAUGGUCAGCAAAGCCAGCAACCUUGAAGGGGGACCUUCUUCUAAUCUCCUCCCUGCCUGCUGAGAGAGUGUACAGAAGCAGCCACUUGUCAGCUGCGAUGAAUCCAAUGAUAAUUACAUAAAUCAUUAACAAUACUUGAUAUUUGCCCAUCACAUUUCUCAUUUCAAAGUGCUCAUAAAAUUGUAUCUCAUGGGUGGCACUGCCGGCACAACAGAAUUCCAAGGAAGGAUUACGGGCUAAGUAAAUAAAGCCUGGAGGCUGCUUU

Taxonomic tree

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