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SNORD36C: SNORD36C is a small nucleolar RNA (snoRNA) that is significantly associated with the expression levels of its host transcript, ribosomal protein L7A (RPL7A), in HD tumors [PMC3511933]. The upregulation of SNORD36C in HD samples is consistent with the global upregulation of the translational machinery, including genes involved in protein biosynthesis [PMC3511933]. SNORD36C is also found to be upregulated in TC2 patients, likely due to its representativeness within HD cases [PMC3511933]. SNORD36C is located on a chromosomal region that has been reported to be transcriptionally active or specifically downregulated in HD patients [PMC3511933]. In hepatocellular carcinoma (HCC), high expression levels of SNORD113-1, a snoRNA similar to SNORD36C, are associated with shorter time to relapse [PMC8677010]. In a study on multiple myeloma (MM), SNORD36C was found to be downregulated in a molecular subgroup of MM patients known as TC2, along with its host gene TAF1D [PMC8629011]. These findings suggest that snoRNAs like SNORD36C may play a role in the overall upregulation or downregulation of the translational machinery and have potential prognostic value in cancer [PMC8629011] [PMC8677010] [PMC3511933].
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