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Homo sapiens (human) p53-induced noncoding RNA (PINCR) URS000020C1DD_9606

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PINCR: PINCR is a human-specific long noncoding RNA (lncRNA) isoform of p53-induced noncoding RNA that plays a critical role in the response to DNA damage [PMC7145678]. PINCR is one of the lncRNAs that were upregulated in all germ layers and stages [PMC7178590]. PINCR has been identified and reported in several diseases [PMC8797667]. PINCR has been shown to play a role in the formation of chromatin loops between promoters and enhancers of p53 target genes [PMC6391031]. PINCR directly binds and recruits Matrin3 to enhancers of p53 target genes that depend on PINCR for p53-mediated induction [PMC7765283]. The expression of RP3-326I13.1 (also known as PINCR) can increase after DNA damage or upon p53 activation [PMC7765283]. DINOL is capable of binding and stabilizing p53, while PINCR controls the expression of genes involved in cell cycle arrest and apoptosis [PMC9861885]. Overall, PINCR is an important lncRNA involved in various biological processes, including DNA damage response, chromatin organization, and regulation of gene expression [PMC7145678, PMC6391031, PMC9861885].

Genome locations

Gene Ontology annotations

Sequence

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AUUCAAUCUGUGAGGUGGAUGCGUGUUGGAAGGACCCCUUUUGGUUUCUUUUUGCUCAGAGCUUUCUUUUAAUAAAUUCCGCUCUCCUCACCUUUCAAUGUGUCCGUAUGCCUAAUUUUUCCUGGUCCUGUGACAAGAACCUGAUUUUAGCUGAACUAAGGAGCGAAAGAUCCUGGAUCAUUUUGGUGACCCAUACUGGUACAUGAGGAAAGCUCCUAUUCCAGAUUCUCAGAGUAUAGAUUCUGACUGGAUUACCCUGGUCCUUGAAGUAUACCUAGGAGAUGGAAUAACAUUGUAUAAGCAUCCACGUUGUCAUUAAGAGGAAAGAGUUUCCAUUAAAACAGCAGGUCACAAAACCCUCCUGUGAGAGGAACCCUCUGUGGAAGAACAGAAUAUGUCACCCCAAAAUAUGAAGAAUUGUUGAGCUGAAGAUGAUUAAGAAGAAGCGGAUGCAGGAAAGCUCUCUGCUCUCCCUCUAUUUGCUUAAAAGCAGGAUAAACACUUACAAAGACUAAAGACGCCACAAUCAAGAACUCAGAAGGGUAGAAGAAAAAGAUAGUUUCCCUUCCCUACACAGGUGUUGAUCCCUUCAUAAAUAUUAUGCAUGCUAAGCCCUAUCUCAAGGUCUACAUCCAGGAGAACCCAACCUGCAACAUUAAGUUACUGACUGUGCAAGAACCCUUUGAUCACGUACCUUACAGACCAAGAUAAGUGAGGAUGCCCAUGUAUAACCUGCUGUCUUUCUGGUCUCUUAUGUUUUUGUACCAGAAAGGGACAACUUUUUGGGUAACCAUAGGUCUCUAGUAUAUCUGUGAUUACAAUAAAGAUUUUUGAUAUACCAAAACUGAUGAACCAAAAUUCCACUGAAAUAGCGAGUAAAUGGAGUUCUUUUAUCCUUUGCAGUAUACCAGGGUGAACUUUUUACAUGAUUUCUUGCUCCAAAGGGAGAAGUGUUAUGACAAAGUACAUUUAAGGACCCUAACUGAUCACAGAAAAAAUAUUAAUGGCAUUGGGAAAAAAAUGCAGACUAAUGAAUCCACUACUAAAUUUUAUCUAUCUUGUAGCUCUAAAAUUGCACUGUUUAGAAUACACUAUGGUAGCCACUAGACAUAUGGCUACUUGAACUUGAAUUGGUUAAAAUCAAAAUUAAGAAUUUAAUUUCUCACUCACAUUAGCCACAUUUCAAGUGCUCAACAGACACAUGUGGCUAGUGUCUACCAUAUUGGACAGCAUAGAUUUAAAGCACAUUUCCAUCAUUGCAACACUGCAAUAUGGAGGAUGUAUCCUCAAUACAUUGAUAUUGCCCCCUCAAAAUUCAUAACCCCUAGAUAUCUUAUCUCUGUAUGUGAGGAUAGUGUAUUAACUUGCACCUGGACUGAGAUAGAUAAAUGCUUAUCUCCAGAGAUGUCUGAAAGUCUGGUACUGACCCUUGUCUAAGAUAAGGAUGGAAUGUGCUGGUUAAUGAUUUAUACUGUGCUAUACAAAGUCCAAAAUUCCUUUGGAGGUAUCCUCUGCUGGCUUGUCUACAUUGUUUAAGGAUGGAUAGGUUGAUGGUUUGCACCUGCUUUAAUCAUUUACACAUUCUGAUUUUAUUUGUGAUCAGUGGAGGAUAAAACCUUCAAUAAACUUGUGUCUUAGCUUCCUUGAUAUUAAGAUAUCUUGCACAUAUCUUAGAUUUUUAUAAUCUGAAUGCAAAGCACAUCCUUUGCAAUUGAGAAAGGACUCUGUGAGCUGCUCCUGGAUAUGUGAAACCCCUCAGUGACUGACCGUAUUUUCUUUCUUCUGCUGUACUUGCCCUUAUUAAAGCCUUACAUGUGAAGUAAGUCCUUUCAAUUGUCUGACUCCGGGUGAUUGUUAUACCCUUUGAUAUAGUUUGGAUAUUUGUGCCUUCCAAAUCUCAUGUUGAAAUGCGAUCCCCUAUGUUGGAGGUGGAGCCUAGUAGGAGGUGUUAGGGUCACGGGAAUGGAUCCCUGAUGAAUGGCUUGGUACACAGUAAUGAGUGAGUUUGUGCUUUAUUAGUUACUGUGAGAUUUACUUGGUAAAAAGAGCCUGGCAACUCCUCCCUCUCCCUUGCUCCCUCUCUUGCCAUGUGACAUGCUUGCUCCAGCUGCACCUUUUGCCACAAUUGUAAGCUUUGUGAGUCCCUCAACAGAAGCUGAGCAAAUGCUGGCACCAUGCUUCUUGUACAGCCUACAGAACUGUGAACCAAAUAAAACUUUUAUUUUUAU

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