hsa-mir-149: Hsa-mir-149 is a microRNA that has been associated with increased or decreased risk of seven different types of cancer, including renal cell carcinoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, papillary carcinoma, and thyroid cancer [PMC6594254]. In a study on osteoarthritis (OA), seven microRNAs were found to have statistically significant differential expression. Among these microRNAs, hsa-mir-149 was downregulated [PMC8966627]. MicroRNAs (miRNAs) are small non-coding RNA molecules that play important roles in gene regulation and have been implicated in various diseases including cancer. Hsa-mir-149 is one such miRNA that has been extensively studied in relation to its association with different types of cancers [PMC6594254]. The association between hsa-mir-149 polymorphisms and increased or decreased risk of various cancers suggests its potential role as a biomarker for these diseases. Understanding the functional significance of hsa-mir-149 in the development and progression of these cancers could provide valuable insights for diagnosis and treatment strategies [PMC6594254]. In the context of osteoarthritis (OA), the downregulation of hsa-mir-149 suggests its potential involvement in the pathogenesis of this disease. Further research is needed to elucidate the specific mechanisms by which hsa-mir-149 contributes to OA development and progression [PMC8966627]. Overall, hsa-mir-149 is a microRNA that has been associated with increased or decreased risk of multiple types of cancers. Its downregulation in osteoarthritis suggests its potential role in this disease as well. Further research is needed to fully understand the functional significance and mechanisms by which hsa-mir-149 contributes to these conditions [PMC6594254] [PMC8966627].