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mmu-mir-149: Helicobacter pylori infection has been shown to silence mmu-mir-149, a microRNA, potentially promoting the pro-tumor properties of stromal fibroblasts and stimulating the production of IL-6 [PMC5576273]. This suggests that H. pylori infection may enhance the pro-tumor properties of stromal fibroblasts by targeting mmu-mir-149 and inducing IL-6 production [PMC4423088]. The targeting of mmu-mir-149 was confirmed by performing a method that verified its interaction with the 3'-UTR of IL-6 [PMC4423088]. Oligonucleotides for mmu-mir-149 mimics, inhibitors, and controls were obtained from GenePharma for further experimentation [PMC4423088]. Additionally, a CpG sites rich region was identified upstream of mmu-mir-149, which is conserved in humans [PMC4423088]. This region may play a role in regulating the expression of mmu-mir-149 [PMC4423088]. Furthermore, differential expression analysis was conducted using primers for various microRNAs including mmu-mir-149 in irradiated vs. control samples [PMC8349067].
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