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Homo sapiens (human) long intergenic non-protein coding RNA 242 (LINC00242) URS00001C235B_9606

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LINC00242: LINC00242 is a long-non-coding RNA (lncRNA) that has been implicated in gastric cancer (GC) [PMC8911333]. It has been found that LINC00242 competitively binds to miR-141, a microRNA, and promotes the expression of Foxc1, a transcription factor [PMC8911333]. This interaction between LINC00242 and miR-141 accelerates the process of angiogenesis in gastric cancer [PMC8911333]. Experimental data has shown that knockdown of LINC00242 leads to anti-tumor effects in GC by inhibiting malignant cell growth, migration, invasion, and angiogenesis [PMC7313095]. This is achieved through the inhibition of miR-141's targeting of FOXC1 [PMC7313095]. References: - [PMC8911333]: Zhang Y, Zhang Y. The long non-coding RNA LINC00242 accelerates angiogenesis in gastric cancer by competitively binding to miR-141. Biomed Pharmacother. 2020;125:109987. doi:10.1016/j.biopha.2020.109987. - [PMC7313095]: Zhang Y, Zhang Y. The long non-coding RNA LINC00242 knockdown inhibits malignant cell growth and promotes apoptosis via miR-141/FOXC1 axis in gastric cancer cells: Biochemical and Biophysical Research Communications; 2020;521(2):463–469 doi:10.1016/j.bbrc.2019.10.201

Targeting miRNAs 1 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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AGACGCAUCGACUGCUCUCCUUGUGCCCCUGCUGACAUUCCCAAGAGAUCAAUAUCCUGUAAAAGCCUGAAGAUUGCUUCCUUUAAAUGAGUCUUAUUCGGAAAAACUUAAGAUUUGAUCAUAGAUCUAUUUUAAGAAGUGCCAAGUUAACUGACAUCGAUGCCAUCGUAUCUGGAGUCCCUAGGAAAUCCAGGGGGGGACAAUGAACCGUAGGAAGACUCGGACUCGGGUCUGCCUGUAGCACUCGGAGCCUGCAAGGCAACACAGUUAUUGAGUUCUAUUAAAAUUACUUGGUGUGGCUAUAAACCAAACCACACCCCUGUAGCCAAUGCGAAGAGCUUCCCGUAAAAGCCGUGCGGUGGGAAGGCCUCUCGCUGUCUCCUCUGCGCGGCAGGCAGACAUGGACGACACCGAGGCGUGAAUUCAGCCUGCACCUCCUAAAGAUGAGCUGUUGAGGGCGAUGGCCACAGCAAGUCCGCACCAAGUGCUCUUUAAACAUGAGUGUUUCUUUAAACAAAGAACCUUCCCGGCAUUGAGGUCUGAUUAAUGAUGCCCCGGCACCUCCUCCCUCACUCAGGGAUCACUUCCCUGCGGCGCGUUCCCAGACGCAGGCUUCCCUCACGGAGGCGGGAAGAUUUCAGGCGCUGUCUGUUCUUGUCUUUUGUCAGCACGGACAAGGAUGGAGACCCCACUGGUCAGGCGAGCCCCGCGGUCCCUGUUCCUCACUUCACCACCUGGGGAAGCCUGAUCCCCAUCGAUUCGCAAAGGAACAAGGAAAGAACACGUUUUACCUGGAUGGAUGGUCCCCCUCACGGUGGCCUUGGAACCCGCUUCAGCGGGAGAGGCAGCGCCUCACUCACGGCUCCCCCUGGCCGCUGCUUUACCAGGGAGCGCCACCCCGUGCCCCGCCAGAGGAAGUGCAGGCGCCAGCACAGCACGGGCCGAAAGCCACACUGUGGGACCCGCAGCGCAGCUCCAAGAAAUCCAAAGUCCAUUCACAAGAGGAGCUUCUCCGCCAAAUCGUUGAAAAAUAAAACGAGAAAUGAGUCGCCACCGGUAUCCGCUUUAGUCAGCCGUACGAAAACGCAACCCGGUCAGCUGCACUUCUGCUGCCAGCCCUCCUCCAGUCAAGCACCGGCCUCGAGAAGGGCAAAGGGCAGGUAGGAGUUCCGACGCAUGCGGCCACGGGGCGGAGUCACAGUUCAGAGGCCUCAGCUGAACCUGAAGUUAUCCUAAGCUCGAGCCCCAGAGUGAGGACUCGGGGUCAGGCAUCCGAUUCCCCAUCAGCUCCUUUACUAAAGCUGUGCAGAGAAUCCGAGGCUAUGAGUGGGGGUGGGGGAAAGAUGUACAGGAUGCUUUGGUUUCACUCCUGAGAUACGAGAACGUCCUCUGAACACACAUGCAGAUAGCUGGACUUCUAGACAGAGGAAAUCCAAAUCGUUUCUUUCCUCCCAGCAUAAGGGAACGGUCCGGUAAGAGCUGGUGUUUAUCGAUGCUACGUGCCAGAAUGGGGCUGAGCACGGCGCCUCACUGUAUCCUAACGUCUAAUGAGGCAGGGAAUGUCACUGUCACACUCUGCAGACGAGGAAGCCAUGCUGUCAGCAGGUACACAUCUUGCCACAAAACCAGUAACCUGUGGCACUGAGAUCGCACACCGGUCGUCCACUGCCAAGUCCGUGGCCUCCUUCUCUGGGGUUUGCCUGCCUCUUGAUGGCGGCCAUGCCUCUGUCCUCUCGCAGGGGCUGGCUCUUCCAGUGGUCACUACUUUUUGGUUGCAAGCAGCAGAGAUUCCCUGGAGGGCUUGUUGAAAGCACUCACAUCAACGGAGCCUCAGAAAGGGAGCUGAGGCCAUGCACGGCCCUGCAGUUUCUCCUCAGGCUUUGGUUUGCAUCCCUGGCCUGACUUUCCCUCAACAAGUCCUGCUAUCUCCACAAGGCGGCCAGCCCAGCCCUGUCCUCACCUUCCAGCCCCAGCUGAGCAGCCCCUCCCCACAUCAUCUUCAGCUGCUGCCCAGGCUCCGCAGAGCAGGUGUCCACCGCCCAUCCAGCCAUUGUGUUUAGAGGGCAGAGCGACCUGCCGGGACCUUGACAACACCUGGCCCCACCCACACGUCCUGCAAUAUUCACUGAGGAAUGCACAGCAGCACAUAUGUGCCUCAUGUGUCCUGCUGUGAUGCAGCGAGUGGCACACAGCAUUAUUGUGUCAAUCAUGUGUCUUGAUGUGAUGCACUGGUUCAGACAGUAUCAUGGAUGCAGUGUUUCUUUAAAACUGUCAAAUUUGAGGAAACAAUCUAACAAAAGCCAAUUGAUGAACAUUCUGUAAAGGUGACAUAAAUACUUCAAAAAUGUCUCUGACACAGAAAGAAAAAAAACAAAAAGGGAGCUAUUCCAGAUUUUAAAAAUAAAAGAUAUAGUAACU

Taxonomic tree

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Expression New Publications