Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
MT-TQ: Because of the positioning of genes, the termination of LSP and HSP1 at a point between mt.3229 (the end of the 16S ribosomal RNA as transcribed by HSP1) and mt.4329 (the end of MT-TQ as transcribed by LSP) would allow the simultaneous utilization of LSP and HSP1 without promoter collision [1]. Moreover, numerous mitochondrial DNA (mtDNA) encoded genes have other rare variants that can cause MELAS; these include mtDNA encoded tRNAs (MT-TS1, MT-TS2, MT-TW, MT-TC, MT-TL2, MT-TK, MT-TH, MT-TQ, MT-TF, and MT-TV) and mitochondrial respiratory chain (MRC) complex I (MT-ND1, MT-ND5, and MT-ND6), complex III (MT-CYB), and complex IV (CIV) subunits (MT-CO2 and MT-CO3) [2]. 1A); mitochondrial tRNA gene MT-TQ was highest ranked among tissue:challenge DEGs (edgeR FDR = 1.3 × 10−4) [3].
References:
[1] PMC6961661
[2] PMC8153374
[3] PMC5453329
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset
