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BCYRN1: BCYRN1, also known as brain cytoplasmic RNA1 (BC200), is a long non-coding RNA (lncRNA) mainly present in neurons. Abnormal expression of BCYRN1 has been associated with neurodegenerative diseases and malignant tumors [PMC10134208]. Knockdown of BCYRN1 and treatment with asparaginase have been shown to significantly increase the apoptotic rate [PMC7738865]. Reduced expression of BCYRN1 has been linked to increased proliferation and migration of glioma cells, leading to unfavorable outcomes in glioma patients [PMC9282894]. LongTarget, a prediction tool, has identified potential binding motifs between BCYRN1 and the WNT5A promoter [PMC8288020]. Exosomal BCYRN1 has been found to enhance lymphatic metastasis induced by VEGF‐C/VEGFR3 signaling in breast cancer, suggesting its potential as a therapeutic target [PMC8831985]. Several lncRNAs, including BCYRN1, have been identified as miRNA "sponges" that regulate the growth of airway smooth muscle cells [PMC5872599]. The correlation between BCYRN1 and epithelial cell adhesion molecule (EpCAM) has also been assessed due to their close relationship with carcinogenesis and tumor progression [PMC5797017]. In hepatocellular carcinoma (HCC), high expression of BCYRN1 is associated with unfavorable prognosis [PMC7552539], while its silencing suppresses tumor development in vivo [PMC9206761]. Knockdown of BCYRN1 inhibits cell proliferation, migration, invasion, and promotes apoptosis in colorectal cancer cells [PMC7491190][PMC8551789][PMC4392634], gastric cancer cells [PMC5797017], non-small cell lung cancer cells (NSCLC) by upregulating MMP9 and MMP13 [PMC9303157], and CRC cells [PMC7491190].
Targeting miRNAs
14 total
According to LncBase, this RNA is targeted by the following miRNAs: