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SNORD41: SNORD41 is a C/D-box small nucleolar RNA (snoRNA) that belongs to a class of regulatory RNAs responsible for ribosomal RNA precursor editing [PMC8038546]. It has been observed that the expression levels of SNORD41 remain similar in tumor samples (19T), matched normal samples (19N), and stroma samples (19S) [PMC8038546]. SNORD41, along with other snoRNAs such as SNORA21, SNORA56, SNORD12B, SNORD12C, and SNORD15A, has been found to play an important role in cancer development [PMC7072173]. In a study on Fib-depletion, it was found that the levels of snoRNAs such as 28S-Am1858 (snoRD38A/B), 28S-Am3703 (snoRD36C), and 28S-Um4276 (SNORD41) were decreased [PMC8677024]. Additionally, in another study on gene expression analysis, it was observed that SNORD41 was one of the most significantly negatively regulated differentially expressed genes [PMC8506768]. In yeast studies involving the dbr1Δ mutant strain and transformation with SNORD41 constructs, it was found that U2-C41 was modified by both independently transcribed and intronic chimeric guide RNAs derived from SNORD41 [PMC8609340]. Furthermore, it has been reported that SNORD41 is located on chromosome 19 along with other snoRNAs such as SNORA68 and SNOR105 [PMC3511933]. Finally, in another study on breast cancer samples, it was found that SNORD41, SNORD83A, and SNORA73B were upregulated, while SNORD59A, SNORD111B, and SNORD119 were downregulated [PMC9803687].
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