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ZBTB40-IT1: ZBTB40-IT1 is a long non-coding RNA (lncRNA) that has been reported to regulate the biological behavior and serve as a prognostic tumor biomarker in various cancer types [57][PMC8855154]. It is included in the prognostic signatures for both progression-free survival (PFS) and overall survival (OS) in cancer patients [57][PMC8855154]. In addition to its role in cancer, ZBTB40-IT1 has been found to regulate bone metabolism by suppressing osteogenesis and promoting osteoclastogenesis [57][PMC7698531]. It modulates the expression of genes involved in bone formation, such as WNT4, RUNX2, Osterix (OSX), ALP, COL1A1, OPG, and RANKL [57][PMC7698531]. ZBTB40-IT1 has also been found to have a correlation with ATM and ASH1L, which are involved in immune response and inflammation modulation [57][PMC6854775]. Furthermore, ZBTB40-IT1 exerts an adverse effect on osteogenic differentiation by modulating WNT4 expression [57][PMC9150698]. In a study on breast cancer patients, ZBTB40-IT1 was identified as one of the m6A-related prognostic lncRNAs associated with breast cancer susceptibility gene BRCA [57][PMC8554333].
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