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MIR219A1: MIR219A1 is a microRNA that is downregulated in the brain of Alzheimer's disease (AD) patients [PMC7564652]. In the cortex of AD patients, MIR219A1 is also found to be downregulated [PMC7564652]. MIR219A1, along with other miRNAs such as MIR29B1, MIR129-2, MIR199A2, MIR92A1, and MIR1296, has been observed to be dysregulated in AD patients [PMC7564652]. Specifically, in AD patients, MIR219A1 targets Tau and its phosphorylation [PMC7564652]. In addition to its role in AD pathology, the microRNA gene MIR219A1 has been associated with significant associations with other loci in genome-wide association studies (GWAS) [PMC4895015]. Furthermore, the expression of MIR219A1 has been found to be altered in various contexts such as pre-miRNAs and miRNAs associated with specific pathways [PMC5538553]. Overall, these findings highlight the importance of understanding the role of microRNAs like MIR219A1 in AD pathology and their potential as therapeutic targets.
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