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Homo sapiens (human) p53 inducible cancer associated RNA transcript 1 (PICART1) URS0000144468_9606

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PICART1: PICART1 is a tumor suppressor gene that plays a role in cell apoptosis and migration [PMC8887966]. It has been found that PICART1 interacts with ARID1A [PMC7202295]. This interaction leads to increased anti-tumor activity of immune cells, which in turn impedes tumor progression [PMC7202295]. Additionally, IL-6 signaling via STAT3 has been shown to promote the maintenance of Th17 cells in inflamed tissue and regulate acute inflammation in various immune cells [PMC7202295]. The JAK2/STAT3 pathway is aberrantly activated when PICART1 is downregulated, which affects cell apoptosis and migration [PMC8887966]. This downregulation of PICART1 also leads to the enhanced release of proinflammatory mediators, such as cytokines and nitric oxide, in STAT3-deficient macrophages and neutrophils upon lipopolysaccharide stimulation [PMC7202295][PMC8887966]. Overall, the interaction between PICART1 and ARID1A as well as the aberrant activation of the JAK2/STAT3 pathway due to downregulation of PICART1 have implications for tumor progression and inflammation [PMC7202295][PMC8887966].

Targeting miRNAs 2 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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GCUGCUGCUGCUGAAAAGGCCAGCCGGGCUGGAGAGACCUGGCAUUGGCGCAUCUGGGAACCGACGUCCGUGCGCGGCUGGCUAGAAUGCUGGACUCGCCUCCGCAGCGCUGGCCUGCAGGGAUUAGAAGACAUGUGGGGUCAAGGAACAGGAAGCUGACCUGGAUGGAAGUUGAACAGUGAUCUUUGCUCUCUGCCUGGCUCCUGAGUCCUCUGCCAUGUUCCUGGAGAAGAGGAGCCAGCCAGGUCUUCAUUCAAACCAAACCUUGGAUGGGAUCCAUCUGCCUCUGCAGGUGACCGUAACAACAUGCAAAUGGUGAGUUCUGCUGGGGGGUCAUGGAAGCUCCCUGGAGGAGGUGUAUCUGGACAACAGGGAAAGAAAGGAGCUGGAGAAGAGAGGCAGAAAAAUUGGGUCCUGGUUCAGGUGAAGUUUUCCCAGCUGGAACAAUGACAAUGUCAAUAUCCCACAAAGGCGGCUUCUGUUUAUUUAGCGCUUGCUGUGUUCCCACAAGUCUUCCUCUACCUGCCCUCUCCCCAGCCCUCAUCUCACUCUCCCAGAGCCCCAGAGCACACCAAUGGACACCAUCACCUCUCGGGCAGAUCAGCACAGAGACGUGAAGCACACAGGCAGCUGCUGGAAAAAUAACAAGGAAUUGCAAUGGUGUGCCCCUCCGUUGAAUGCAAGCUCUCUUCUGCCUUCUCACCUUGGGCAAGUUACCUUCCGUUCCAGGCCUCGGUUUCUCCAUGUGUGAAAUGAAAGGGCUGGAGAGAAAUCUCUCACUAUUCCCCAAUCUACAUUCAUUGUAUCCCAAACCUUCUAAUAUCUGUUCAACGAAGUGUACCAAAUCUCAGCUAUUGGACUGAGACUCAGGGGUCUAUCUGACUUGAAUUGAAAAUGCAAAUUACUGAAGAGGGAGGGAGGGAGGAGUGCUGAAGAUUGAAUGGAUUUAUCAGAUUUCCUUCUCCUAUGGCCCAGAUGCAGGCCUAGUCCAGGCGAUUCCCCUGGCUCAGAAUCUGCCAGGCUCAAGCAUUCAUUGACAGCCUACUAUGUACCAAUCCUGGGCUGAGUCCCAACCCGGGGAUGACUUAGAGGAGGCCAGGAUGUGGCCUCAUGUUCUGGUUGCUCUCACAUUUAAACAGGCUAAACCCACUUUGCAUUGUAUGUUAGGGGUGGUGCUUGUGGGACAAAGGGGGCUGUCAGAACAUUCUGGCUGCCACAUGAAGUUGACUUUGCCAGGACAGACUGGGUUGUGGGGGAAGGCAGCUACUGUAAUAAUUUGGCCAAGAAGUGGGCUGAGCAGGAGCAGGGCUGAGGGAGGGAGAGAGGGAAUGAGUAAGAAAGGCCCAGGGUACUGAUUUGACUGGGACUUCAGGGACAGGUGUGGGGCGAGAGGGAUGCUGGAAGUGAAGGAGGGAAAGUGCAGAGGCUUUCUGGGGAUUAAUAGGCAAUGAUCUCUAUGAGGGCGUGGUGAGUAGGCCCCAAACAUCCGGGGACUUCCCUGCCUGCCAUCCCUCUGUCUCUCUCUUCCUUUCCUACUGCCCAGGGCCUGGCCCUGCUGCACAUGCCCUGCCCUGGCCCCCAGAGUCCCCUUCUUUCCUGGCUGGGAGAUUAAGACUCUGCUGUGCCUACAGCAUUCUCAACCUCAAGUCAAGGUGGCCCUUUGGAGCCCAGGAGGCCACAUGGCUGAGUCAGGGCUGAGUCACCACCCCCCAAGGGCCUUGCCAUUUCCUGUGGAGAAGCCUCUUUACUGGCAGGGUUCUGUGCUCAGGUGGGAAAUCUGGAGAGGUCGGGGGCAGGGCUUCAUCUACUUUUACCCACUAACUCCCUAGACACUCCACUGGGGGUAGAGGGUUCCUACACGUAUGAUGAUCAAAACAUGUGUCUGUGCACAUGGGCCCUUAUGCAUUCACAGGUGUUUGCCUAUGCGACUGCAUGUCUGAAUGUUUUAUGUAUAUUUGAAUAUAGAUAGGGAACAAAUAUUUAUGGAGCACAUAUUAUGUGUGCAGCCUUUUACGUGUGUUACUUUCUAAUAACCCUAGGAGGCGUAGAUGCCUCCCAGGCUAUGGUUGAAAAUACUGACAUGCCCAAGGUGCAGGAGGUAUGAAUACCUCCCCACUGUGGCUGGUAACACCCCAGGUUUCUCCAACUCCACAGUGAUGGGCUUUCCUCCAGAGCCGGUUCCUCAGGGGCAGGAGUGAGAAGUGUGUGUGUCUGUAUUUAUCCUUCCACCAGUGGCUGUGAUUGGUCCUGUGGUUGGAAACAGGGUCAAGUAAGGCCCUUGGGAGUAGCUGGGUGAAUGGACGAUGGUGGCGUCCACCUUGGACAUGGCACAUACUUCUGGUCGGGUAUCCACGUGGCUGGCCAACCCGGACCUGCCCUAUUAGGGGCCAUCGCCCUCAUGGCUCAUCAGUGCUGAGUUUCAUUGCCUUCUUCGUAAUGCAAUACUAAUGGAUACAGGCAUGUAUCUGCCGUACACUAGAUGAAAUGUGGUUAUUUGCUCAGGUAGAAAUAAAGACUAAAAUACCAAAGUGGG

Taxonomic tree

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Expression New Publications