hsa-mir-382: hsa-mir-382, a microRNA, has been predicted to have two binding sites on the REST transcript, one at the first exon and one at the 3′ UTR, as determined by UCSC miRcode [PMC4297868]. In a study comparing control neurons and neurons derived from Fragile X Syndrome (FXS), it was found that hsa-mir-382 exhibited high levels in control neurons but markedly low levels in FXS-derived neurons [PMC4297868]. HNMT, a gene involved in histamine metabolism, is regulated by several microRNAs. Hsa-miR-3202 regulates HNMT in a culture with adalimumab [PMC9678002]. Hsa-miR-583 regulates HRH1 (a histamine receptor) independent of the drug added to the culture [PMC9678002]. Hsa-miR-1275 regulates SLC23A2 and HRH3 (histamine receptors) [PMC9678002]. Hsa-miR-4696 regulates HRH3 in a culture with CSA (cyclosporine A) [PMC9678002]. Additionally, hsa-mir-382 regulates HNMT in a culture with adalimumab [PMC9678002]. References: [PMC4297868] - Darnell JC et al. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell. 2011 Jan 21;144(2): 253–265. [PMC9678002] - Gao Y et al. Identification of miRNA–mRNA regulatory network associated with adalimumab treatment for rheumatoid arthritis by integrated analysis. BMC Musculoskelet Disord. 2021;22(1): 1005.