hsa-mir-33b: hsa-mir-33b is a microRNA that is involved in various biological processes and has been implicated in multiple types of human cancers [PMC6451803]. It has been shown to bind to the 3' UTR of several genes, including COL1A1, COL3A1, COL4A1, COL6A3, SPARC, THBS2, and VCAN [PMC6009060]. In gastric cancer, hsa-mir-33b is one of the miRNAs that potentially affect development and prognosis by regulating hub genes [PMC6009060]. It has also been found to be dysregulated and prognosis-related in ovarian cancer [PMC6451803]. In hepatocellular carcinoma (HCC), hsa-mir-33b is downregulated and suppresses the proliferation and metastasis of HCC cells through the inhibition of Sal-like protein 4 (SALL4) [PMC6451803]. Furthermore, hsa-mir-33b can inhibit lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signaling [PMC6451803]. In cholangiocarcinoma (CCA), low-expression levels of hsa-mir-33b are associated with poor overall survival (OS) in patients [PMC6451803]. However, there are no reports on the involvement of hsa-mir-33b in osteoarthritis pathogenesis or CCA regulatory mechanisms remain largely unclear [PMC5728069] [PMC6451803].