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Homo sapiens (human) microRNA hsa-mir-215 precursor URS00000F31F4_9606

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hsa-mir-215: Hsa-mir-215 is a microRNA (miRNA) that has been studied in various contexts. It has been identified as one of the miRNAs with 20 or fewer validated targets in miRTarBase, along with hsa-miR-21-5p and hsa-miR-124-3p [PMC5484592]. In certain studies, hsa-mir-215 has been found to be significantly associated with target genes involved in specific pathways [PMC8876010]. It has also been suggested as a potential prognostic indicator for chemotherapeutic benefits in STS metastasis [PMC4434893]. In the context of colorectal cancer (CRC), hsa-mir-215 has shown associations with disease stage and CRC-specific mortality [PMC6007480]. Additionally, hsa-mir-215 has been found to be upregulated in NPM1 mutated AML compared to NPM1 wild-type AML [PMC7851519]. It is worth noting that hsa-mir-215 exhibits a high correlation with Esophageal Neoplasms [PMC6929455]. In tumor tissues, the expression of hsa-mir-215 is significantly lower compared to adjacent normal colon epithelial tissue [PMC8798538]. Furthermore, it has been identified as one of the miRNAs involved in specific molecular mechanisms, acting as a direct inhibitor for certain targets [PMC8233096]. In different studies, it was found to be both upregulated and downregulated depending on the context and disease type.

MIR215: MIR215 is a microRNA that is involved in various biological processes and has been studied in different contexts. It has been shown to be downregulated in a cycling hypoxia-selected subpopulation, along with miRNA200c and miR205 [PMC3046435]. MIR215 functions as a suppressor of epithelial-mesenchymal transition (EMT) by targeting the mesenchymal transcription factor ZEB2 and increasing the expression of E-cadherin [PMC3046435]. In APC mutant tumors, MIR215 is repressed, while miR708, miR135b, and miR3 are upregulated [PMC8450413]. In senescent cells, MIR215 is expressed at higher levels compared to early passage cells [PMC2815728]. It has also been shown that MIR215 expression is positively correlated with the expression of its host gene IARS2 in colon tissues [PMC7377047]. In adenocarcinoma, melatonin regulates the interplay between FoxO1, miR96, and MIR215 signaling [PMC8998229]. The upregulation of MIR215 has been associated with worse prognosis in stage II colorectal cancer patients [PMC7912746]. Stress-related microRNAs such as miR-34, miR-192, and MIR215 are produced in a p53-dependent manner in response to DNA damage [PMC2868896]. In pancreatic cancer, downregulation of MIR192 and MIR215 suppresses tumor proliferation by suppressing the tumor suppressor activity of SMG1 [PMC9790066]. The expression of MIR215 has also been identified as part of a top-ranked microRNA expression signature layer [PMC9284388]. Mammalian studies have shown that p53 transcriptionally activates miR192, miR194, and MIR215 [PMC9743578]. MIR215, along with miR192, induces cell cycle arrest and increases the expression of p27-Kip1 [PMC5764254]. The expression of MIR215 and miR192 is upregulated by t10,c12 CLA treatment, leading to an increase in p27/Kip-1 expression [PMC5764254]. The upregulation of miR184 and MIR215 is associated with cell cycle arrest, but the mechanism behind this upregulation is not clear [PMC5764254]. The expression of MIR215 has been examined in various studies using different techniques such as qPCR and cDNA synthesis [PMC5949293] [PMC6120784]. Additionally, MIR215 has been found to be correlated with WBC count and CRP levels in certain contexts [PMC8358855]. Overall, MIR215 is a microRNA that plays a role in various biological processes and has been implicated in different diseases such as cancer. It functions as a suppressor of EMT and cell proliferation by targeting specific genes. Its expression can be regulated by different factors such as hypoxia, DNA damage, and treatment with specific compounds.

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Gene Ontology annotations

Sequence

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AUCAUUCAGAAAUGGUAUACAGGAAAAUGACCUAUGAAUUGACAGACAAUAUAGCUGAGUUUGUCUGUCAUUUCUUUAGGCCAAUAUUCUGUAUGACUGUGCUACUUCAA

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This sequence is found in 1 other species

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