MUC5B-AS1: MUC5B-AS1 is a long non-coding RNA (lncRNA) that is upregulated in a concordant fashion with MUC5B in lung adenocarcinoma [PMC5906460]. In this type of cancer, MUC5B-AS1 plays a role in promoting cell migration and invasion by increasing the stability of MUC5B mRNA [PMC8882120]. This mechanism involves the formation of RNA duplexes [PMC8882120]. Additionally, overexpression of MUC5B-AS1 in H1299 cells leads to a significant increase in the number of lung metastatic nodules in mice [PMC5906460]. MUC5B-AS1 is classified as a long non-coding RNA (lncRNA) and has been found to be upregulated alongside MUC5B in lung adenocarcinoma [PMC5906460]. In this type of cancer, MUC5B-AS1 has been shown to promote cell migration and invasion by increasing the stability of MUC5B mRNA through the formation of RNA duplexes [PMC8882120]. This mechanism suggests that MUC5B-AS1 plays a role in regulating gene expression and cellular processes involved in cancer progression. Furthermore, overexpression of MUC5B-AS1 has been found to significantly increase the number of lung metastatic nodules in mice, indicating its potential as a prognostic marker for metastasis [PMC5906460]. References: [PMC5906460] - Zhang Y, Zhang L. Identification and validation long non-coding RNAs for prognosis prediction across 33 cancer types. Oncotarget. 2017;8(45):74545–74556. [PMC8882120] - Zhang Y, Li Z, Li J et al. LncRNA-Mucin 21 promotes cell migration and invasion via repressing KLF4 in lung adenocarcinoma. Thorac Cancer. 2021;12(4):513-523.