Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
MIR181A2: MIR181A2 is a microRNA that can be transcribed from two different genes, MIR181A1 and MIR181A2, and is regulated by multiple transcription factors and enhancer/promoter regions [PMC8979821]. Overexpression of MIR181A2 has been associated with various types of cancer [PMC6781644]. In a hyperglycemic state, the lncRNA MIR181A2 is downregulated, leading to an increase in the concentration of certain microRNAs [PMC9430013]. Overexpression of MIR181A2 has been shown to downregulate PCAF mRNA and protein levels [PMC5573355]. The downregulation of MIR181A2 by HIV vEnv glycoprotein is associated with enhanced viral transcription and infectivity [PMC5573355]. Lentiviral particles expressing MIR181A2 have been used to transduce T cells, resulting in reduced HIV transcription [PMC5573355]. The downregulation of MIR181A2 may be a natural host mechanism targeted by HIV to activate viral transcription [PMC5573355]. The host gene for MIR181A2, known as MIR181A2HG, has been found to be overexpressed in the thyroid but its function remains unknown [PMC6380385]. The expression levels of AKT2 have been investigated as potential targets for miR-181-3p and miR-181-5p derived from the host gene MIR18IAHG [PMC7891834]. In various tissues, including the human body's nucleus, the host gene for MIRA18IAHG is expressed [PMC10111190]. In different studies, miR-18IAHG has shown potential as a biomarker for certain diseases such as diabetes and cancer but its function remains unclear in these contexts.
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset