hsa-mir-517a: Hsa-mir-517a is a miRNA that is differentially expressed upon NaB-induced differentiation and is classified as an ES miRNA [PMC2581805]. Mutations in hsa-mir-517a have been associated with lower cancer stages and improved patient survival [PMC7648123]. Hsa-mir-517a is one of the miRNAs analyzed using TaqMan® MicroRNA assays [PMC5496854]. It has been identified as one of the hub genes in a study [PMC9851797]. Hsa-mir-517a is highly decreased in NSC cells compared to iPSC, suggesting its role as a negative regulator of neural differentiation from iPSC [PMC6696086]. It has also been implicated in the transition from ES to NSC and may be characteristic for iPSC to NSC transition [PMC6696086]. Hsa-mir-517a belongs to the Hsa-miR-517 family, which includes hsa-mir-517c and hsa-mir-519a, all transcribed from the C19MC cluster [PMC8666996]. It has been suggested that hsa-miR-519a, along with other differentially expressed miRNAs including hsa-miR-205 and hsa-miR-1, may be involved in the regulation of p53-signaling and apoptosis related genes in recurrent miscarriage pathogenesis [PMC4829624]. High expression of hsa-mir-517a has been associated with worse prognosis for tumor progression/recurrence-free survival and overall survival in glioblastoma patients [PMC6990552]. Additionally, hsa-mir-517a has been identified as one of the crucial miRNAs involved in diminishing pluripotency state and chondrogenic process [PMC6770352].