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hsa-mir-25: Hsa-mir-25 has been found to have more targets in TargetScan compared to most other miRNAs, but fewer targets in miRanda [PMC5581471]. It is also one of the predicted miRNAs for ERS signature genes EDEM1 and BAX [PMC9022475]. In a miRNA expression profiling study, hsa-mir-25 was found to be upregulated in COLO 320 and COLO 205 cells, which are involved in the regulation of cell cycle, cell differentiation, migration, and invasion [PMC9941246]. Additionally, hsa-mir-25 has been implicated in the invasion of prostate cancer and may be involved in signaling mechanisms related to aurora kinase A or integrin [PMC8426106].
MIR25: Using pcDNA3-MCM7-S, heterologous hairpin structures were inserted into the original positions of miR-106b, miR-93, and MIR25 as XhoI/HindIII, EcoRI/BamHI, or XbaI/SacII fragments, respectively [PMC3155610]. Overexpression of MIR25 and miR93 stimulates activation of the AKT signaling pathway, leading to stimulation of cell survival, proliferation, and invasiveness [PMC9864244]. The potential role of MIR25 and miR186 in systemic lupus erythematosus (SLE) has not been explored as extensively as that of miR21 [PMC9013931].
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