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Homo sapiens (human) DBH antisense RNA 1 (DBH-AS1) URS00000AF948_9606

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DBH-AS1: DBH-AS1 is a long non-coding RNA (lncRNA) that has been investigated for its relationship with HBx and its role in hepatocellular carcinoma (HCC) progression [PMC4741803]. It has been found that HBx can upregulate the expression of DBH-AS1, leading to increased cell proliferation through the activation of MAPK signaling in HCC [PMC7848407]. Overexpression of DBH-AS1 in HepG2 cells has been shown to elevate the expression of oncogenic cell-cycle regulators, such as CDK6, CCND1, and CCNE1, while reducing the expression of cyclin-dependent protein kinase inhibitors like p16, p21, and p27 [PMC4741803]. These findings confirm the regulatory mechanism of DBH-AS1 in HCC progression [PMC4741803]. Additionally, a deficiency in DBH-AS1 has been shown to enhance pancreatic cancer cell proliferation by promoting downregulation of USP44 [PMC9011309]. These results highlight the importance of DBH-AS1 in cancer development and progression.

Genome locations

Gene Ontology annotations

Sequence

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GGAGUGCAGACCCAUCACCCCUCACUGGGGCCCCCCAUGAGGCCUGCCUGACUGCAUGCCCCACCCGGGCCCAUGGCAGCGCACCUGGAAGCGGACGGCUGAGGACUUGUUGCAGUGCAUGGAGAUGGGCGCGAAGCUGUACAGGGCCUUCAGUACGUCGCGGUUGAAGGAGUUCCAGGGAACAGAGGAUCCCGAAGCCCCCCUGCAAGUUGGAGGAGACCCGUCAGCCCCGGGCCAUGCCACGCAGACGCUGCCAUCCAGCAGCUUUCGCCGCACCCACGUGUACACUGCGUCCACUCGUCUGUUCACUGCACCGUGCCAGGCAUGCUCUGGGGAACCGAGUCCCUGCCCUCAAGGAAUUGCCACCAUUGGCAGGAGAGACAGGCAGUGAGUGAGUGAGUCAACCAGGAAAUUCGUAUCAGGUACUGAUGAUGCUGUGAGGAAAAAUGAAACGGGACAAGCGGAUGGGGUGUUAUUGUGCCCAUUUUAUGGGUACAGAAACUGAGUCUCAGAGCAGGCAAGGGGAUGCCCCGUGGUGGCCACAGCAUCGGUGGCACAGCCUGAGUGCACCCAGCGUCCCGGCCAUUGUCUGGAAGCUGUCCCCAUGACCUCCAGCGAGAGCCUGGAGCCAAGGACUGCAAGGGAGGCCCUUUCCACUGCAGCCCCGCACCGUCCACCAGUCAUUUCUCCAACGUGGCUCUGAGGGGAGCAGGGACUCUAUAAGACAGGACCGUGACUAGAGGCCGCGACAACCUCCAGCCUCUCACGGCAACCCUACGGCCUGCCAUCGCAUGGGAGGGGCAGGGCAGGCACCCUCUGAGUCCCCACUGCCAGCUUUAAGCCCCUCGCUGGGUUGCUGCUCUUGGAGCUGGUGACCGUGGAGCCUCAGCCAUAGGAGGAAGAACAGCAGCAGCUUGGAGGAGCUGGGGCUGGAGAGAGCAAAGCUCCCCCGGCAGCAGCUCAGAUCCCAGCAGGUCAGGGGCCGGGACAUGACGCCCUGGCCACCCUUGCCCCUCCAGGCUCCCCGCUGUUUGUGAAGCUGCUGUGGGCCUGGGGAUUUCAUCUGGCUGGUGGGGAAGAAAGGCAAUCUUUACUCUAUGGCAGAACAAAGGGACUGGGCAAAGCUUGGCGUGGCACUUACACCAGCUGCCGCCCCCUCCUCCCGUGCAGACAAAGAGCAUGGGACAGUUCUGCCCAGAGACGAAACCUGGCACCUGUUGGCCAGGACGCGUUUUUGCCAGCAUUGUUCUCUGGGCCGGAUUCCUCCUUUCCCAGCUUUUCUCAUCCAUCCCGCCCCCGUCAGAUCGGGACGAUUGCCCUCCUGUGUGAGUUCCUGUCCCUCCCCACCCUCUGCCACCACAGACAUCAAAAGGGAACUGAGUCCGACCCUGUGUAGAAUCUGUUCUCCUCUUUCACCUGGGGAAGGAAAUCGAAUUUCAAAGGCCACUGUGUCUUGGAUCAGCAGGCGAGGGCUUGUCAGAGUGUGAGAAGCUCAGGUCCACCUGGGGAGCUGCCCUCCCCUUUGAUCCCACCUGGUGCUGUGAUGUGGCCACUGCCAAGAGGACGACAUGGGCCAGGGAAGCCACAGAACUGCCCACGGGGACGCUGGCACCGAGGGCCUCAACCUGCAGAACGGCCAUCUGAGAUGUCCGCGGUGCUCACCAGGCCUGGCAGCCCCGAACGCCCUGGGACGUGGCGUCAGUUCCGCCGCCGUGAAGCCAGAUUGGGCAGGGAAUAUGCAGUCUCCUCGCUGGAUGCCCGGCAAGACCCUCCCAUCCCUGGCCCCGGGGCCGCGCCUGCAGAAUGGGGCUGAUGGUGGGGACUUGCCUGGGGUGCUCCACCUGCAGAGCCCUCUGUUUGCGAGCCCACUCAGUCACUGCACAGGUGCUUAGCCGAGAGGCGGCACAGUCGGGGUUGGCACCUGCACCCAUACCAGCCCUGCCUCCUGUUCGCUGUGUGGCCUGAGUGGCUGGACCUCACUGUAUCUCCUGGUGGGAUUGCUCAGAGGUCUCAGCAAGGCUUGGUGUGGUUAGGAUGAGUUAUUAGAGCAGUGCUGAGCUGUGGCAAGCACCCGACAUCAGCCACUGCUGUGAUAUACUGAGCACCUCCUCUAGAGAGAAUAAAGGACUGACAAAGCUG

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Publications