hsa-mir-4497: Hsa-mir-4497 is a microRNA that has been observed to be induced in HaCaT cells exposed to UVB radiation [PMC9224968]. It has also been found to augment lipopolysaccharide (LPS)-stimulated TNFα expression [PMC6823203]. Hsa-mir-4497, along with hsa-mir-4420 and hsa-mir-4429, has been identified as a possible new microRNA involved in regulating malignant human B cells [PMC4231109]. In a study examining exosomes released from CPT-treated hepatoma cells, hsa-mir-4497 was found to be downregulated [PMC10135778]. Hsa-mir-4497 is associated with severe malaria symptoms such as prostration, multiple seizures, severe anemia (SA), and acute respiratory distress (ARD) [PMC7853565]. It was also found to be positively correlated with HRP2 levels in malaria patients [PMC7853565]. In qPCR assays, hsa-mir-4497 was one of the eight differentially expressed miRNAs that were analyzed [PMC6823203]. Overall, hsa-mir-4497 shows potential as a proxy marker of malaria severity and may have implications in the regulation of malignant human B cells and UVB radiation-induced responses in keratinocytes.