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Homo sapiens (human) long intergenic non-protein coding RNA 52 (LINC00052) URS000004E371_9606

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LINC00052: LINC00052 is a long non-coding RNA (lncRNA) that has been implicated in breast cancer (BC) progression. It has been suggested that LINC00052 may promote cell proliferation and metastasis in BC by regulating TGFBR2 [PMC7988718]. The correlation between LINC00052 and HER3 expression has also been investigated, and breast cancer cells expressing ectopic HER3 were used to confirm this relationship [PMC5351650]. Additionally, LINC00052 has been found to influence β-catenin methylation, with its silencing inhibiting β-catenin methylation and its overexpression promoting it [PMC7841087]. Furthermore, in vitro experiments have shown that overexpression of LINC00052 leads to downregulation of IGF2 [PMC8798243]. However, the mechanisms by which LINC00052 upregulates EPB41L3 to inhibit tumor cell migration and invasion are still not fully understood [PMC5609956].

Genome locations

Gene Ontology annotations

Sequence

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ACUCAGCUCUCUCACCAUGCGAUUGCCCUGCAACACCUUGGAACUCUGCAGAGAGUCCCCAGCAGGAAGGUCUCACCUGAGGUGAACCUUCGACCUUGGACUUCUCAGCCUCCAGAAUGAAGAAUGGCAACCAUCAAAUCAAGAAAUUGGCCCAAAGCCCUACAGUCUGCAAACAUCAUAACAAUUCAUCCUGAAGUUUCUCCAUGAAUUGUGAUGCUUUGCUACAUCAUUCUGCAAUCCCAGAAGAUUUUUUGCAUAUUUUUUUGCUAUUACAGAAAAAUCUCAGUCUCCCUCCCUCUCUCUCUCUCUCAAUCUGUGUGUCUCUUUUACUCCAUAUCUCUGUGUGUGUCUCUUUUACUCCAUAUCUCUCUGUGUGUGUCUGUUUAUGUCUCUCUCUCUCUCUCAUCCUUCCCAUGUUUCUCUCUCACACACACACACACUCAUUCACAGCUUUCAAAAGACACGUCUGUCCUUACCUUCACUUUUUGUUUUAAACAGCACACUCACUUUACUCUGAACUAUACCUCACAUGCACACGAGCUUUCUGCUCCAUCUGUUCAUCCCACAUGUGUCUUCACAUUCAAAGCAGCACCUUCCCCAAGACCAGCUACCUAACCACCUCCCACCUCCACCCCAUCCCUAGUCAGAGGAAGGCCUGGUUCCCACCUGAAUUCAGCUUUGUCAAAGAGCCUCCUGGAAAGCUGUCAUCUUCAGUUAGUAGGGAUAAUGGGAUUAUUCUAUCUGUGUAAUAAUAACAUGUUCAAUUUAAAGAAAAAAAUCUGAAGCCACUUAAAAGCUACUGUUUGGCACCGAUACAUUAUUCCAGUAAUGAAUAAUCAUUAAAGAUAUUAUUCUGGAUGCAGUUACCAUGCAGUGAUGUGAAUAAAAUGCAUUAGAUGGAAAAUUGUAUUUCAAGUAAAUAUAUGCACUGGUAGAAAUGUAUUACCACCCACUAAUAUGUAUUAAUUCAAAACCAAAUGCCAACUGGAGUUCGCCUACACGGGUUUGAAUGGCAGGCAGUGAUUUGGAAGUGGGAGGAAAUAGGUUUGGAUUUGGUCAAAUAGACUGAGAAGUGAUAGUGGGGGCGGGGGUUUAUGACUCAAACUUUAACAGGUGAGAAGACUAUGCCAUGGACAGAACAGGCAUGAGGGGCUCCCCUCCUACGCCUCUUUAAGAGAUUUUUAUCUCUGACUAAGGAUUACUGGUAGUUGUUGACAUUUCUGAAGCAGUGGAUCUUUUUCCUUUUUCACUAUCUGCAUCUUCAAAUAUUCUUUUCUGAAGAAAGUUAAAAGGAAGCCUGUACAUUUUUUGCUAAGGUAAAUGCCUUGCCAUCUUAUUUCAUUUUCUCAUUUUUUUCUUCAGUGCACAACAUAAGCAACUGUCCUCCUUGUCAUACUCAAGAUGAGCUUGGCAUAUCUGAAAUCUGCAGGGAUUUUCUCAUUAGCACAGGGUUCCAAGCCCAAACCGUGAAGAUGGAGUUUUCAUUUUUAAAUGGCACAUCUUCAAGUUCUUGCCCUGUCCUCACUUUAGUAUGCCCCAGAGGAAGUCAAAGAUAUGGACACUCUAAGACUCAGAAGAACUUUCUCAGGCAUUCAUUUUCCUAUCUAUUUUGAGCCAUUUUAUUUAAAAGGUUACAAUUUUAAACCUCUCUUUAAUUAAAAGAUACCAGAGUUACAAUGCAAUACUAUUUGGCAAUCAAAACUAAUGAAGCACAGAUGCAUGCUACAACACGAAUGAACUUUGAAACGUUGUGUUAAGUGAAAUAAACCAGUUAUUAUACAAGGCC

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Publications